rs657152
A SNP in the ABO gene on chromosome 9. Its most notable genotype is A;A: A few different minor risk associations; see details
- Gene
- ABO
- Location
- Chr 9133,263,862 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 38%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs657152 on the minus strand: (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 38% A;A 15%
- European ancestry (Utah)C;C 38% A;A 13%
- Han Chinese (Beijing)C;C 43% A;A 15%
- Japanese (Tokyo)C;C 33% A;A 13%
- Yoruba (Nigeria)C;C 32% A;A 18%
- African ancestry (Southwest US)C;C 29% A;A 15%
- Chinese (Denver)C;C 46% A;A 8%
- Gujarati IndianC;C 34% A;A 21%
- Luhya (Kenya)C;C 25% A;A 16%
- Mexican ancestry (Los Angeles)C;C 63% A;A 11%
- Maasai (Kenya)C;C 33% A;A 17%
- TuscanC;C 39% A;A 21%
Related
Conditions, medicines and genes
Other ABO SNPs
- rs505922C;Cblood type is not O, increased risk for some diseases.Worth knowing
- rs1008708453A;AO2 alleles (ABO Type O) may be presentWorth knowing
- rs2519093C;Ccommon/normalTypical
- rs7853989C;CLikely blood group BTypical
- rs8176719-;-likely to be of blood type OTypical
- rs8176740A;ANo summary available.Typical
- rs8176743C;CNo summary available.Typical
- rs8176746T;TType B blood group (of ABO system)Typical
Notes
From SNPedia
Notes
The T allele of this SNP is associated with very slightly higher risk of pancreatic cancer. Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function. Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin. Genetic variants associated with Von Willebrand factor levels in healthy men and women identified using the HumanCVD BeadChip.
Source and license
Adapted from rs657152 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.