rs8176746
A SNP in the ABO gene on chromosome 9. Its most notable genotype is T;T: Type B blood group (of ABO system)
- Gene
- ABO
- Location
- Chr 9133,255,935 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 12%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableNot ratedType B blood group (of ABO system)
- G;TNot ratedType B blood group (of ABO system); one allele
- G;GNot ratedNo summary available.
SNPedia records rs8176746 on the minus strand: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 3% G;T 23% G;G 74%
- European ancestry (Utah)T;T 0% G;T 15% G;G 85%
- Han Chinese (Beijing)T;T 7% G;T 28% G;G 66%
- Japanese (Tokyo)T;T 2% G;T 35% G;G 64%
- Yoruba (Nigeria)T;T 3% G;T 27% G;G 69%
- African ancestry (Southwest US)T;T 5% G;T 14% G;G 81%
- Chinese (Denver)T;T 2% G;T 25% G;G 73%
- Gujarati IndianT;T 8% G;T 35% G;G 57%
- Luhya (Kenya)T;T 5% G;T 24% G;G 72%
- Mexican ancestry (Los Angeles)T;T 0% G;T 16% G;G 85%
- Maasai (Kenya)T;T 2% G;T 21% G;G 77%
- TuscanT;T 1% G;T 15% G;G 84%
Related
Conditions, medicines and genes
Other ABO SNPs
- rs505922C;Cblood type is not O, increased risk for some diseases.Worth knowing
- rs657152A;AA few different minor risk associations; see detailsWorth knowing
- rs1008708453A;AO2 alleles (ABO Type O) may be presentWorth knowing
- rs2519093C;Ccommon/normalTypical
- rs7853989C;CLikely blood group BTypical
- rs8176719-;-likely to be of blood type OTypical
- rs8176740A;ANo summary available.Typical
- rs8176743C;CNo summary available.Typical
Genosets
- Gs129Unable to classify the ABO blood typeWorth knowing
- Gs130AB blood groupWorth knowing
- Gs131B blood groupWorth knowing
- Gs132A blood group; AA or AO at molecular levelWorth knowing
- Gs133B blood groupWorth knowing
- Gs135This genoset identifies an ABO blood group where Type B is likely but Type A possible. Type B from B+O more likely (~8% Caucasian) than Type A.Worth knowing
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Notes
This SNP is a variant in the ABO gene, and is therefore potentially useful in determining ABO blood group, such as through the use of genosets. 23andMe reports this as a G/T while decodeme reports it as an A/C.
Source and license
Adapted from rs8176746 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.