Heart disease

71 SNPs linked to Heart disease across 42 genes, 31 with a genotype of magnitude 2 or higher.

Type: Condition
SNPs: 71
Notable: 31Magnitude 2 or higher
Well documented: 54
Genes: 42

Linked SNPs

Every genotype, as shown in 23andMe and AncestryDNA files.

rs1800562LOC108783645Very important
- A;ATwo copies of C282Y, likely affected by hemochromatosis which may be serious if male or post-menopausal.Bad
- A;GOne copy of C282Y, carrier of hemochromatosis, likely unaffected unless also H63D carrier.Bad
- G;GNot a C282Y hemochromatosis carrier.Good
rs1333049Very important
- C;C1.9x increased risk for coronary artery diseaseBad
- C;G1.5x increased risk for CADBad
- G;GnormalGood
rs1801282PPARGImportant
- C;Cnormal fat metabolism; common in clinvarGood
- C;GUnconfirmed higher risk of cardiovascular disease with high saturated fat dietBad
- G;GUnconfirmed higher risk of cardiovascular disease with high saturated fat dietBad
rs2383206CDKN2BASImportant
- A;AnormalGood
- A;G1.4x increased risk for heart diseaseBad
- G;G1.7x increased risk for heart diseaseBad
rs4420638APOC1Important
- A;ANormal/Average risk for Alzheimer'sGood
- A;G~3x increased Alzheimer's risk; 1.4x increased heart disease risk ; increased LDL cholesterolBad
- G;G2x+ increased Alzheimer's risk, further genotyping suggested ; increased LDL cholesterolBad
rs5082APOA2Worth knowing
- G;Gsaturated fat contributes to obesity, but 0.57 % lower risk for coronary artery diseaseNot rated
- A;Gnormal riskNot rated
- A;Anormal riskNot rated
rs5918ITGB3Worth knowing
- C;CMI risk, aspirin resistanceBad
- C;TMI risk, aspirin resistanceBad
- T;TaverageGood
rs187238IL18Worth knowing
- G;Ghypertension not a risk factor for sudden cardiac deathGood
- C;Ghypertension not a risk factor for sudden cardiac deathGood
- C;Chypertension increases risk 3.75x for sudden cardiac deathBad
rs1800629TNFWorth knowing
- A;Acomplex; generally higher risk for certain diseasesBad
- A;Gcomplex; generally higher risk for certain diseasesBad
- G;Gcomplex; generally normal riskGood
rs2943634Worth knowing
- A;Alower risk of ischemic strokeGood
- C;Cslightly higher risk of ischemic strokeBad
rs4986790TLR4Worth knowing
- A;AnormalGood
- A;GNo summary available.Not rated
- G;Gcomplex; numerous associations reportedBad
rs4986791TLR4Worth knowing
- C;CnormalGood
- C;Tcomplex; see detailsNot rated
- T;Tcomplex; see detailsNot rated
rs10757278Worth knowing
- A;A0.78x reduced risk for Coronary Heart Disease. 0.77x reduced risk for Brain Aneurysm and Abdominal Aortic Aneurysm.Good
- A;G1.3x risk for Heart Attack. Normal risk for Abdominal Aortic Aneurysm and Brain Aneurysm.Bad
- G;G1.6x risk for Heart Attack; 1.3x risk for Abdominal Aortic Aneurysm and Brain Aneurysm.Bad
rs1024611CCL2Worth knowing
- G;Gincreased risk of exercise induced ischemia, Increased CCL2 levels; increased rate of HIV progressionBad
- A;Gincreased risk of exercise induced ischemiaBad
- A;Anormal riskGood
rs268LPLWorth knowing
- A;Acommon in clinvarGood
- A;G3X increased risk for venous thromboembolismBad
- G;G3X+ increased risk for venous thromboembolismBad
rs4961ADD1Worth knowing
- G;GnormalGood
- G;T1.8x increased risk for high blood pressureBad
- T;T1.8x increased risk for high blood pressureBad
rs2070744NOS3Worth knowing
- C;Cincreased prostate cancer riskBad
- C;TNo summary available.Not rated
- T;Tcardiovascular differencesGood
rs662PON1Worth knowing
- T;T~2x higher risk of of coronary heart disease reported in some studies, but lower risk seen in other studiesBad
- C;T0.65x lower risk of ovarian cancer; higher risk of coronary heart disease in some studies; somewhat reduced PON catalytic efficiencyNot rated
- C;CMixed; conflicting results reported related to stroke and CADNot rated
rs5174LRP8Worth knowing
- T;T1.3x increased risk for heart diseaseBad
- C;T1.3x increased risk for heart diseaseBad
- C;CNormal risk for heart diseaseGood
rs17576MMP9Worth knowing
- A;Anormal risk for lung cancer; higher risk for MINot rated
- A;Ghigher risk for MI and lung cancer, and COPD in smokersBad
- G;Ghigher risk for lung cancer, and COPD in smokers; normal risk for MIBad
rs174537MYRFWorth knowing
- G;Gcommon; higher LDL-C and total cholesterolNot rated
- G;Tcommon; higher LDL-C and total cholesterolNot rated
- T;Tlower LDL-C and total cholesterolGood
rs383830Worth knowing
- T;T1.9x riskBad
- A;T1.6x riskNot rated
- A;AnormalNot rated
rs688034SEZ6LWorth knowing
- C;CnormalNot rated
- C;T1.1x risk higher risk for coronary artery diseaseBad
- T;T1.6x riskBad
rs854560PON1Worth knowing
- A;Ahigher risk for heart disease, diabetic retinopathyBad
- A;Thigher risk for heart disease, diabetic retinopathyBad
- T;T0.5x lower risk of ovarian cancerGood
rs1800795IL6Worth knowing
- C;Cless IL6; certain risks, see detailsBad
- C;Gcomplex; see detailsNot rated
- G;Gmore IL6; certain risks, see detailsBad
rs2298566SNX19Worth knowing
- A;AnormalNot rated
- A;Cincreased risk of coronary heart disease; better response to statinsNot rated
- C;Cincreased risk of coronary heart disease; better response to statinsNot rated
rs6922269MTHFD1LWorth knowing
- A;A1.6x risk of coronary artery diseaseBad
- A;G1.2x risk of coronary artery diseaseBad
- G;GnormalNot rated
rs7250581Worth knowing
- A;AnormalNot rated
- A;GnormalNot rated
- G;G1.4x riskBad
rs17228212SMAD3Worth knowing
- C;C>1.26x increased risk for heart diseaseBad
- C;T1.26x increased risk for heart diseaseBad
- T;TnormalGood
rs17672135FMN2Worth knowing
- C;CnormalGood
- C;TReduced risk (0.7x) for heart diseaseGood
- T;T1.3x risk of heart diseaseBad
rs34210653ALOX15Worth knowing
- G;Gnormal riskGood
- A;G1.6x increased risk for heart diseaseNot rated
- A;AReduced risk for nasal polyps and chronic sinusitisGood
rs1010VAMP8Minor
- T;Tnormal risk of MINot rated
- C;T1.75x risk of MIBad
- C;C1.75x risk of MIBad
rs8055236CDH13Minor
- A;ANo summary available.Not rated
- G;Gcommon, but 2.2x higher risk for heart diseaseBad
- G;T1.9x risk for heart diseaseBad
- T;TnormalNot rated
rs501120Minor
- T;Tcommon, but >1.3x increased risk for heart diseaseBad
- C;T1.3x increased risk for heart diseaseBad
- G;GNo summary available.Not rated
- C;CnormalNot rated
rs599839PSRC1Minor
- A;A1.4x increased risk for heart diseaseBad
- A;G1.3x increased risk for heart disease; slightly lower (0.8x) risk for abdominal aortic aneurysmBad
- G;Gmoderately lower (0.64x) risk for abdominal aortic aneurysmGood
rs1801020F12Minor
- G;GNormal risk of developing heart diseaseGood
- A;G1.31x increased risk of heart diseaseBad
- A;A1.31x increased risk of heart diseaseBad
rs17465637MIA3Minor
- A;ANo summary available.Not rated
- A;C1.17x higher risk for myocardial infarctionBad
- C;C1.34x higher risk for myocardial infarctionBad
rs429358APOEMinor
- C;Cone of 2 snps relevant to classifying APOE genotypeBad
- C;T>3x increased risk for Alzheimer's; 1.4x increased risk for heart diseaseBad
- T;TcommonGood
rs4880SOD2Minor
- G;Gcomplex! see rs4880Not rated
- A;Gcomplex! see rs4880Not rated
- A;Acomplex! see rs4880Not rated
rs3803GATA2Typical
- G;Gcommon in clinvarGood
- C;CNo summary available.Not rated
rs5065NPPATypical
- A;A1.12x risk on diuretic; if hypertensive, better outcome when treated with calcium channel blocker than with diureticGood
- A;Gnormal riskNot rated
- G;G0.87x risk on diuretic; if hypertensive, better outcome when treated with diuretic than with calcium channel blockerGood
rs8089LOC101929523Typical
- C;Cslightly increased heart attack riskBad
- A;Cslightly increased heart attack riskBad
- A;Anormal riskGood
rs20455KIF6Typical
- G;GNo summary available.Not rated
- A;GNo summary available.Not rated
- A;Acommon in clinvarGood
rs788016HSPD1Typical
- A;GNo summary available.Not rated
rs1048990PSMA6Typical
- C;C> 1.48x riskBad
- C;G1.48x riskBad
- G;GcommonNot rated
rs1799983NOS3Typical
- G;Gnormal riskNot rated
- G;Tincreased risk of preeclampsiaNot rated
- T;Tincreased risk of preeclampsia, also heart diseaseNot rated
rs2713604GATA2Typical
- A;GNo summary available.Not rated
rs3900940MYH15Typical
- C;Cslightly increased risk of coronary heart diseaseNot rated
- C;Tslightly increased risk of coronary heart diseaseNot rated
- T;TnormalNot rated
rs3918242MMP9Typical
- C;Cnormal riskNot rated
- C;T1.14x increased risk for MI; also check haplotypeNot rated
- T;T1.33x increased risk for MI; also check haplotypeNot rated
rs7439293PALLDTypical
- A;Aincreased risk of coronary heart disease; better response to statinsNot rated
- A;Gincreased risk of coronary heart disease; better response to statinsNot rated
- G;GnormalNot rated
rs10489535ACOT7Typical
- G;GNo summary available.Good
rs10498345Typical
- A;A<0.5x decreased risk for coronary spasmNot rated
- A;T0.5x decreased risk for coronary spasmNot rated
- T;TnormalGood
rs10510468PLCL2Typical
- G;Gcommon in complete genomicsGood
rs10757274CDKN2B-AS1Typical
- A;AnormalNot rated
- A;G~1.2x increased risk for heart diseaseBad
- G;G~1.3x increased risk for heart diseaseBad

Genes

KIF65
MYH155
PALLD5
SNX195
VAMP85
APOE2
GATA22
MMP92
NOS32
PON12
TLR42
TNF2

Genosets

Gs2162 copies of the APOE-ε4 alleleVery important

Genosets combine several genotypes. Twofold checks them in your report.

Other SNPs

No notable genotype or detailed notes

Show 17 SNPs

rs39317
rs287354
rs287474
rs752658
rs815160
rs966376
rs1171381
rs1550922
rs1676232
rs2286983
rs2305560
rs2340690
rs2565163
rs2827196
rs3091244
rs4404477
rs11039155

Source and license

Adapted from Heart disease on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.