rs187238

rs187238, also known as -137 G/C, is a SNP in the interleukin 18 IL18 gene. Based on studying autopsies of 700 men in the Helsinki Sudden Death Study, there was a significant interaction between IL-18 genotype and hypertension impacting on the risk of sudden cardiac death (SCD) due to coronary heart disease (CHD). Among rs187238(G;G) homozygotes, hypertension was a major risk factor for SCD due to CHD (adjusted odds ratio 3.75, CI:1.78-7.91, p < 0.001) and hypertension also associated with larger coronary atherosclerotic plaque areas (p = 0.002) and the occurrence of complicated plaques (adjusted OR 8.38, CI: 2.39-29.33, p < 0.001). Among rs187238(C) allele carriers, hypertension was not a significant risk factor for CHD-related SCD or CAD and did not associate with the development of coronary atherosclerotic plaques. Interleukin-18-promoter polymorphisms are not relevant in rheumatoid arthritis. Association study of functional genetic variants of innate immunity related genes in celiac disease. Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing. Interleukin 18 and human immunodeficiency virus type I infection in adolescents and adults. Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA). NeuroD1 gene and interleukin-18 gene polymorphisms in type 1 diabetes in Dalmatian population of Southern Croatia. Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population. Interleukin-18 promoter polymorphism associates with the occurrence of sudden cardiac death among Caucasian males: the Helsinki Sudden Death Study. Interleukin-18 gene polymorphisms and haplotypes in patients with oral lichen planus: a study in an ethnic Chinese cohort. Polymorphism of interleukin-18 promoter influences the onset of kidney graft function after transplantation. Interleukin (IL)-18 polymorphism 133C/G is associated with severe respiratory syncytial virus infection. Promoter polymorphism of interleukin-18 in angiographically proven coronary artery disease. Interleukin-18 promoter polymorphisms and risk of late onset Alzheimer's disease. Novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery. Interleukin-18 gene (IL18) promoter polymorphisms in patients with rheumatoid arthritis. Impact of interleukin-18 polymorphisms-607 and -137 on clinical characteristics of renal cell carcinoma patients. Haplotype analysis of the interleukin-18 gene in Czech patients with allergic disorders. Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study. Inflammatory mediators gene polymorphisms in preeclampsia. Analysis of interleukin-18 promoter polymorphisms and changes in interleukin-18 serum levels underscores the involvement of interleukin-18 in recurrent spontaneous miscarriage. Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality. Association of polymorphisms in interleukin-18 and interleukin-28B with Hepatitis B recurrence after liver transplantation in Chinese Han population. Interleukin-18 promoter polymorphisms and risk of idiopathic recurrent pregnancy loss in a Tunisian population.