rs8089

A SNP in the LOC101929523 gene on chromosome 6. Its most notable genotype is C;C: slightly increased heart attack risk

Gene
LOC101929523
Location
Chr 6169,217,631 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
18%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableBadslightly increased heart attack riskTypical · 0.04% of people
  2. A;CBadslightly increased heart attack riskTypical · 0.028% of people
  3. A;AGoodnormal riskTypical · 0.069% of people

SNPedia records rs8089 on the minus strand: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 4% A;C 28% A;A 69%
  • European ancestry (Utah)C;C 5% A;C 39% A;A 56%
  • Han Chinese (Beijing)C;C 0% A;C 17% A;A 83%
  • Japanese (Tokyo)C;C 2% A;C 20% A;A 79%
  • Yoruba (Nigeria)C;C 6% A;C 32% A;A 62%
  • African ancestry (Southwest US)C;C 7% A;C 28% A;A 65%
  • Chinese (Denver)C;C 2% A;C 20% A;A 78%
  • Gujarati IndianC;C 3% A;C 17% A;A 80%
  • Luhya (Kenya)C;C <1% A;C 29% A;A 70%
  • Mexican ancestry (Los Angeles)C;C 2% A;C 28% A;A 70%
  • Maasai (Kenya)C;C 6% A;C 35% A;A 59%
  • TuscanC;C 8% A;C 39% A;A 53%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 150 words

rs8089, a SNP in the thrombospondin-2 THBS2 gene, was studied as part of a large study (>5,000 Caucasian patients) for risk of myocardial infarction and thus heart disease. Although statistically not overwhelming, a risk was seen (odds ratio 1.19, CI: 1.02-1.39, compared to (T;T) homozygotes) for carriers of the less common rs8089(G) allele. In a meta-analysis combining several studies, no statistically significant association for heart attacks was seen for rs8089, nor for that matter, 2 other SNPs, rs2228262 (also known as Asn700Ser) or rs1866389 (also known as Ala387Pro), in thrombospondins -1 and -4, respectively. A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. An association study of thrombospondin 1 and 2 SNPs with coronary artery disease and myocardial infarction among South Indians.

Source and license

Adapted from rs8089 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.