rs17672135

A SNP in the FMN2 gene on chromosome 1. Its most notable genotype is T;T: 1.3x risk of heart disease

Gene
FMN2
Location
Chr 1240,282,296 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
11%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodnormalTypical · 0.01% of people
  2. C;TGoodReduced risk (0.7x) for heart diseaseMinor · 1.418% of people
  3. T;TMost notableBad1.3x risk of heart diseaseWorth knowing · 2.081% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 1% C;T 18% T;T 81%
  • European ancestry (Utah)C;C 3% C;T 22% T;T 75%
  • Han Chinese (Beijing)C;C 2% C;T 17% T;T 81%
  • Japanese (Tokyo)C;C 3% C;T 26% T;T 72%
  • Yoruba (Nigeria)C;C 0% C;T 15% T;T 85%
  • African ancestry (Southwest US)C;C 0% C;T 19% T;T 81%
  • Chinese (Denver)C;C 0% C;T 17% T;T 84%
  • Gujarati IndianC;C 2% C;T 29% T;T 69%
  • Luhya (Kenya)C;C 4% C;T 15% T;T 82%
  • Mexican ancestry (Los Angeles)C;C 0% C;T 12% T;T 88%
  • Maasai (Kenya)C;C 0% C;T 12% T;T 89%
  • TuscanC;C 2% C;T 14% T;T 84%

Conditions, medicines and genes

Other FMN2 SNPs

All FMN2 SNPs

Notes

From SNPedia

Notes

rs17672135 has been reported in a large study to be associated with heart disease, in particular, coronary artery disease. The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 0.70 (CI 0.61-0.81), and for homozygotes, 1.32 (CI 0.79-2.22).

C;T

Reduced risk (0.7x) for heart disease

Source and license

Adapted from rs17672135 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.