rs1799983
A SNP in the NOS3 gene on chromosome 7. Its most notable genotype is G;G: normal risk
- Gene
- NOS3
- Location
- Chr 7150,999,023 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 20%
Genotypes
As shown in 23andMe and AncestryDNA files.
- G;GMost notableNot ratednormal risk
- G;TNot ratedincreased risk of preeclampsia
- T;TNot ratedincreased risk of preeclampsia, also heart disease
On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageG;G 73% G;T 26% T;T 2%
- European ancestry (Utah)G;G 39% G;T 54% T;T 8%
- Han Chinese (Beijing)G;G 78% G;T 22% T;T 0%
- Japanese (Tokyo)G;G 86% G;T 14% T;T 0%
- Yoruba (Nigeria)G;G 87% G;T 13% T;T 0%
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
rs1799983 (also known as Glu298Asp, E298D, or G894T) located in the NOS3 gene was associated with an ~2x risk (p=0.006) of developing pre-eclampsia (pregnancy-induced hypertension) and further complications of it in a study of ~50 African women. A large meta-analysis combining 26 studies (9,867 patients) found that homozygosity for rs1799983(T;T) increases risk of ischemic heart disease. The odds ratio was 1.31 (CI: 1.13-1.51). However, a study of 1,600 Greek patients concluded that rs1799983 was not associated with risk of acute myocardial infarction in that population. left ventricular hypertrophy in human essential hypertension OR=1.5
Source and license
Adapted from rs1799983 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.