rs4496877

A SNP in the NOS3 gene on chromosome 7. Its most notable genotype is T;T: For type-1 diabetics, 1.6x increased nephropathy risk

Gene
NOS3
Location
Chr 7150,983,418 (GRCh38)
Highest magnitude
1.2Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
22%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GNot ratedNo summary available.Typical · 0.072% of people
  2. G;TNot ratedFor type-1 diabetics, 1.3x increased nephropathy riskMinor · 1.123% of people
  3. T;TMost notableBadFor type-1 diabetics, 1.6x increased nephropathy riskMinor · 1.25% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 72% G;T 23% T;T 5%
  • European ancestry (Utah)G;G 36% G;T 48% T;T 16%
  • Han Chinese (Beijing)G;G 79% G;T 20% T;T 2%
  • Japanese (Tokyo)G;G 80% G;T 20% T;T 0%
  • Yoruba (Nigeria)G;G 100% G;T 0% T;T 0%
  • African ancestry (Southwest US)G;G 84% G;T 16% T;T 0%
  • Chinese (Denver)G;G 80% G;T 18% T;T 3%
  • Gujarati IndianG;G 64% G;T 28% T;T 8%
  • Luhya (Kenya)G;G 99% G;T <1% T;T 0%
  • Mexican ancestry (Los Angeles)G;G 60% G;T 33% T;T 7%
  • Maasai (Kenya)G;G 82% G;T 18% T;T 0%
  • TuscanG;G 27% G;T 55% T;T 19%

Conditions, medicines and genes

Other NOS3 SNPs

All NOS3 SNPs

Notes

From SNPedia

Notes

rs4496877 is a SNP near the NOS3 gene. Several Type-1 diabetes patients pools, totaling over 2,000 patients, plus a meta-analysis were involved in a study concluding that in such patients, the rs4496877 was associated with higher risk for nephropathy. The odds ratio associated with rs4496877(T) was 1.26 (p = 0.002, CI: 1.08-1.47). A proxy for this SNP (pairwise linkage of 0.96) is rs1800783.

Source and license

Adapted from rs4496877 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.