rs891512

A SNP in the NOS3 gene on chromosome 7. Its most notable genotype is A;A: Higher blood pressure than G;G

Gene
NOS3
Location
Chr 7151,011,001 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
12%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadHigher blood pressure than G;GImportant · 3.0<1% of people
  2. A;GBadHigher blood pressure than G;GWorth knowing · 2.515% of people
  3. G;GGoodLower blood pressure than those with an A alleleTypical · 0.184% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A <1% A;G 15% G;G 84%
  • European ancestry (Utah)A;A <1% A;G 33% G;G 66%
  • Han Chinese (Beijing)A;A 0% A;G 14% G;G 86%
  • Japanese (Tokyo)A;A 0% A;G 4% G;G 96%
  • Yoruba (Nigeria)A;A 0% A;G 0% G;G 100%
  • African ancestry (Southwest US)A;A 0% A;G 12% G;G 88%
  • Chinese (Denver)A;A 0% A;G 5% G;G 95%
  • Gujarati IndianA;A 2% A;G 19% G;G 79%
  • Luhya (Kenya)A;A 0% A;G <1% G;G 99%
  • Mexican ancestry (Los Angeles)A;A 0% A;G 24% G;G 76%
  • Maasai (Kenya)A;A 0% A;G 8% G;G 92%
  • TuscanA;A 5% A;G 51% G;G 45%

Other NOS3 SNPs

All NOS3 SNPs

Notes

From SNPedia

Show notes, about 140 words

rs891512 (also known as G24943A, IVS25+15 [G&#8594;A]) is an intronic variant in the NOS3 gene significantly associated with blood pressure. The intronic variant, IVS25+15 [G-->A], was significantly associated with blood pressure; GG homozygotes had significantly lower levels of diastolic blood pressure (DBP) (-2.8 mm Hg; P = 0.016) and systolic blood pressure (SBP) (-1.9 mm Hg; P = 0.018) than A-allele carriers. eNOS polymorphism rs891512 (G24943A) is associated with hypertension in Chilean individuals (p<0.05). Two specific SNPs in significant LD with each other (rs891512 and rs1808593) were significantly associated with ABI (ankle-brachial index) in both subsets. protective haplotype C-T-A (rs2070744-rs1799983-rs891512) was observed (P = 0.01) with a pronounced effect against suicide completion (P = 0.005).

Source and license

Adapted from rs891512 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.