rs3918227
A SNP in the NOS3 gene on chromosome 7. Its most notable genotype is C;C.
- Gene
- NOS3
- Location
- Chr 7151,003,858 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 6%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 10 HapMap populations.
- AverageC;C 91%
- European ancestry (Utah)C;C 75%
- Han Chinese (Beijing)C;C 86%
- Japanese (Tokyo)C;C 91%
- Yoruba (Nigeria)C;C 100%
- Chinese (Denver)C;C 90%
- Gujarati IndianC;C 91%
- Luhya (Kenya)C;C 99%
- Mexican ancestry (Los Angeles)C;C 97%
- Maasai (Kenya)C;C 99%
- TuscanC;C 85%
Related
Notes
From SNPedia
Notes
Habitual energy expenditure modifies the association between NOS3 gene polymorphisms and blood pressure. Nitric oxide synthase genes and their interactions with environmental factors in Parkinson's disease. NOS3 variants, physical activity, and blood pressure in the European Youth Heart Study. Association of NOS3 tag polymorphisms with hypoxic-ischemic encephalopathy.
Source and license
Adapted from rs3918227 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.