rs2070744
A SNP in the NOS3 gene on chromosome 7. Its most notable genotype is T;T: cardiovascular differences
- Gene
- NOS3
- Location
- Chr 7150,992,991 (GRCh38)
- Highest magnitude
- 2.1Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 26%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CBadincreased prostate cancer risk
- C;TNot ratedNo summary available.
- T;TMost notableGoodcardiovascular differences
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageC;C 0% C;T 0% T;T 100%
- European ancestry (Utah)C;C 0% C;T 0% T;T 100%
- Han Chinese (Beijing)C;C 0% C;T 0% T;T 100%
- Japanese (Tokyo)C;C 0% C;T 0% T;T 100%
- Yoruba (Nigeria)C;C 0% C;T 0% T;T 100%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 210 words
The NOS3 gene encodes nitric oxide synthase 3, and is also known as eNOS; rs2070744 is a SNP in the promoter region that is associated with higher levels of the corresponding mRNA (and possibly protein). Associations for the risk allele (C) of this SNP include: * Rheumatoid Arthritis , and, * cardiovascular mortality in high-risk patients * Progression (but not occurence) of prostate cancer Men who carry the C allele responded more favorably to the antihypertensive effects of aerobic exercise Current HapMap data for this SNP appears wrong (ss42994451). The population diversity information is instead being estimated based on ss48295994 P1, and should be replaced what a new HapMap ss# is available.
T;T
This is found in high frequency male athletes from power sports such as jumpers, throwers, and sprinters. There may be negative health consequences with increased risk of cardiovascular disorders. and response Mexicans with this SNP, and also a T at rs1800783, have lower LDL cholesterol. People with this SNP, and also a T at rs1800783, may be less responsive to hypnosis. Notably, this SNP does not change the amino acid (it is in the promoter region and doesn't encode the protein's amino acid sequence). The population frequencies in HapMap are incorrect.
References
Source and license
Adapted from rs2070744 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.