Rheumatoid arthritis

104 SNPs linked to Rheumatoid arthritis across 38 genes, 21 with a genotype of magnitude 2 or higher.

Type: Condition
SNPs: 104
Notable: 21Magnitude 2 or higher
Well documented: 57
Genes: 38

Linked SNPs

Every genotype, as shown in 23andMe and AncestryDNA files.

rs6920220Important
- A;A1.7x risk of Rheumatoid ArthritisBad
- A;G1.2x risk Rheumatoid ArthritisBad
- G;GnormalGood
rs7574865STAT4Important
- G;Gnormal risk of rheumatoid arthritis, SLE, Sjögren's syndrome, type-1 diabetes, and primary biliary cirrhosis.Good
- G;T1.3x risk of rheumatoid arthritis; 1.55x risk of SLE; 1.42x risk of Sjögren's syndrome; increased risk of type-1 diabetes; and increased risk of primary biliary cirrhosis.Bad
- T;T1.69x risk of rheumatoid arthritis; 2.4x risk of SLE; 2.28x risk of Sjögren's syndrome; increased risk of type-1 diabetes; and increased risk of primary biliary cirrhosis.Bad
rs2476601PTPN22Important
- A;A2x risk of rheumatoid arthritis and other autoimmune diseasesBad
- A;GIncreased Risk of Multiple Autoimmune DisordersBad
- G;GNormal risk for autoimmune disordersGood
rs6311HTR2AImportant
- C;C3.6x increased risk of sexual dysfunction when taking SSRI Antidepressants.Bad
- C;TNormal risk of sexual dysfunction when taking SSRI Antidepressants.Good
- T;TNormal (lower) risk of sexual dysfunction when taking SSRI Antidepressants.Good
rs6679677RSBN1Important
- A;A5.2x risk for T1D; 3.3x for RABad
- A;C1.8x risk for T1D; 2x risk for RABad
- C;CnormalGood
rs660895Worth knowing
- A;AnormalGood
- A;Gpossibly at 4x higher risk of rheumatoid arthritisBad
- G;G6x higher risk of rheumatoid arthritisBad
rs1800629TNFWorth knowing
- A;Acomplex; generally higher risk for certain diseasesBad
- A;Gcomplex; generally higher risk for certain diseasesBad
- G;Gcomplex; generally normal riskGood
rs2004640IRF5Worth knowing
- G;Gnormal; 0.9x decreased risk for rheumatoid arthritisGood
- G;T1.4x increased risk for SLEBad
- T;T1.4x increased risk for SLEBad
rs3738919ITGAVWorth knowing
- A;ANormal risk of developing rheumatoid arthritisGood
- A;C1.94x risk of developing rheumatoid arthritisBad
- C;C1.94x risk of developing rheumatoid arthritisBad
rs2837960LINC00323Worth knowing
- G;G2.3x rheumatoid arthritis riskBad
- G;TnormalNot rated
- T;TnormalNot rated
rs3761847TRAF1Worth knowing
- A;AnormalGood
- A;G1.32 x risk of rheumatoid arthritis.Bad
- G;G>1.32 x risk of rheumatoid arthritisBad
rs6313HTR2AWorth knowing
- G;Ghigher risk for RABad
- A;Ghigher risk for RABad
- A;Adepression, panic, stress responseBad
rs2070744NOS3Worth knowing
- C;Cincreased prostate cancer riskBad
- C;TNo summary available.Not rated
- T;Tcardiovascular differencesGood
rs2230926TNFAIP3Worth knowing
- G;G1.4x risk of rheumatoid arthritisBad
- G;T1.4x higher risk for rheumatoid arthritisBad
- T;Tcommon in complete genomicsGood
rs6457617Worth knowing
- C;CnormalGood
- C;T2.3x risk of rheumatoid arthritisBad
- T;T5.2x risk of rheumatoid arthritisBad
rs763361CD226Worth knowing
- C;CNormal risk for multiple autoimmune diseasesGood
- C;TSlightly increased risk for multiple autoimmune diseases, such as type-1 diabetesBad
- T;TIncreased risk for multiple autoimmune diseasesBad
rs1800795IL6Worth knowing
- C;Cless IL6; certain risks, see detailsBad
- C;Gcomplex; see detailsNot rated
- G;Gmore IL6; certain risks, see detailsBad
rs6910071C6orf10Worth knowing
- A;AnormalGood
- A;Gpossibly at 4x higher risk of rheumatoid arthritisNot rated
- G;G6x higher risk of rheumatoid arthritisBad
rs10499194Worth knowing
- C;CnormalNot rated
- T;Tprotective against rheumatoid arthritis for asiansGood
rs13207033Worth knowing
- A;Areduced risk of rheumatoid arthritisGood
- A;GNo summary available.Not rated
- G;GnormalBad
rs2269475AIF1Minor
- T;Tincreased rheumatoid arthritis riskBad
- C;Tincreased rheumatoid arthritis riskBad
- C;CnormalNot rated
rs2488457PTPN22Minor
- G;Gcommon/normalGood
- C;GSlightly increased (~1.5x) risk for certain autoimmune diseases in some populationsBad
- C;CSlightly increased (~1.7x) risk for certain autoimmune diseases in some populationsBad
rs33996649PTPN22Minor
- C;Ccommon in complete genomicsGood
- C;TSlightly lower (~0.8x) risk for rheumatoid arthritisGood
- T;TSlightly lower (~0.65x) risk for rheumatoid arthritisGood
rs729302Minor
- A;ANormal risk of developing rheumatoid arthritisBad
- A;C0.89x decreased risk of developing rheumatoid arthritisGood
- C;C0.89x decreased risk of developing rheumatoid arthritisGood
rs1801274FCGR2AMinor
- G;Gnormal risk for cancer progressionGood
- A;Gcomplex; generally greater risk for cancer progressionBad
- A;Acomplex; generally greater risk for cancer progressionBad
rs2240340PADI4Minor
- T;Tslightly increased (1.5x) risk for RABad
- C;Tslightly increased (1.5x) risk for RABad
- C;CaverageGood
rs2280714TNPO3Minor
- T;T1.4x increased risk of SLEBad
- C;T1.4x increased risk of SLEBad
- C;CNormal risk of SLEGood
rs3087243CTLA4Minor
- A;ANormal risk for auto-immune diseasesGood
- A;Gincreased risk for auto-immune diseasesBad
- G;GIncreased risk for autoimmune diseasesBad
rs6427528CD84Minor
- A;Afor rheumatoid arthritis patients, better response to etanercept treatmentGood
- A;Gfor rheumatoid arthritis patients, better response to etanercept treatmentGood
- G;GcommonGood
rs12212067FOXO3Minor
- G;GLower inflammatory responseNot rated
- G;TLower inflammatory responseNot rated
- T;TGreater inflammatory responseNot rated
rs7528684FCRL3Minor
- A;A0.73x reduced risk of Graves' diseaseGood
- A;GnormalNot rated
- G;G1.2x risk of Rheumatoid Arthritis; various risks of autoimmune diseasesBad
rs3748079ITPR3Typical
- T;Tnormal riskNot rated
- C;Tnormal riskNot rated
- A;GNo summary available.Not rated
- C;C1.9x increased risk for SLE (lupus)Bad
- A;ANo summary available.Not rated
rs4678VARS2Typical
- G;Gcommon in clinvarGood
rs6314HTR2ATypical
- G;Ghigher risk for RABad
- A;Ghigher risk for RA; better response to paroxetine as treatment for depressionBad
- A;AaverageNot rated
rs396991FCGR3ATypical
- C;CnormalNot rated
- A;Ccomplex; generally greater risk for cancer progressionNot rated
- A;Acomplex; generally greater risk for cancer progressionGood
rs743777IL2RBTypical
- A;ANo summary available.Not rated
- A;GNo summary available.Not rated
- G;GRisk allele associated with rheumatoid arthritisBad
rs1328674HTR2ATypical
- T;Thigher risk for RANot rated
- C;Thigher risk for RANot rated
- C;CaverageGood
rs1343151IL23RTypical
- G;Gnormal riskNot rated
- A;G0.8x lower risk for spondylitisGood
- A;A0.8x lower risk for spondylitisGood
rs1953126PHF19Typical
- C;CnormalNot rated
- C;T1.3x increased risk for rheumatoid arthritisNot rated
- T;T1.3x increased risk for rheumatoid arthritisNot rated
rs1982073TGFB1Typical
- G;Grisk genotype for several disordersNot rated
- A;Grisk genotype for several disordersNot rated
- A;Arisk genotype for several disordersNot rated
rs2073838SLC22A4Typical
- G;GNo summary available.Not rated
rs2076530LOC101929163Typical
- T;T2x risk for sarcoidosisBad
- C;Tincreased risk for sarcoidosisBad
- C;CnormalNot rated
rs3213422DHODHTypical
- A;Acommon in clinvarGood
rs3766379CD244Typical
- C;CnormalNot rated
- C;T1.37x increased risk for rheumatoid arthritisBad
- T;T1.9x increased risk for rheumatoid arthritisBad
rs3789604RSBN1Typical
- G;G1.7x increased RA riskBad
- G;T1.5x increased RA risk; 1.4x increased GD riskBad
- T;Tnormal for RA; 1.4x increased GD riskNot rated
rs3792876SLC22A4Typical
- C;CNo summary available.Not rated
rs3816587ANAPC4Typical
- C;C1.3x riskBad
- C;TnormalNot rated
- T;TnormalNot rated
rs3817964LOC101929163Typical
- T;TnormalGood
- A;Tpossibly at 4x higher risk of rheumatoid arthritisNot rated
- A;A6x higher risk of rheumatoid arthritisNot rated
rs5029937TNFAIP3Typical
- G;GNo summary available.Good
rs6682654CD244Typical
- A;ANo summary available.Not rated
- A;G1.34x increased risk for rheumatoid arthritisBad
- G;G1.8x increased risk for rheumatoid arthritisBad
rs6684865MMEL1Typical
- A;A1.5x risk of rheumatoid arthritisBad
- A;G1.2x risk of rheumatoid arthritisBad
- G;GnormalNot rated
rs6822844Typical
- G;Gcommon on affy axiom dataGood
rs9550642LOC100133618Typical
- A;A2.2x riskBad
- A;G1.3x riskBad
- G;GnormalGood
rs9826828STAG1Typical
- G;Gcommon genotypeGood
rs10818488TRAF1Typical
- A;A2.1x increased risk for rheumatoid arthritisBad
- A;G1.4x increased risk for rheumatoid arthritisBad
- G;GnormalGood
rs11162922Typical
- A;A2x riskBad
- A;G1.3x riskBad
- G;GnormalNot rated
rs11761231Typical
- A;ANo summary available.Not rated
- C;CNo summary available.Not rated
- C;TNo summary available.Not rated
- T;TnormalNot rated
rs9268839HLA-DRB9Worth knowing
- A;Acommon/normalGood
- A;G2x increase in rheumatoid arthritis risk (in Caucasians)Bad
- G;GModerately (~4x) increased rheumatoid arthritis risk (in Caucasians)Bad

Genes

HTR2A4
PTPN224
IRF53
C52
CD2442
LOC1019291632
RSBN12
SLC22A42
TNFAIP32
TRAF12
AIF11
ANAPC41

Genosets

Gs108Rheumatoid arthritis riskWorth knowing

Genosets combine several genotypes. Twofold checks them in your report.

Other SNPs

No notable genotype or detailed notes

Show 46 SNPs

Source and license

Adapted from Rheumatoid arthritis on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.