rs3816587

A SNP in the ANAPC4 gene on chromosome 4. Its most notable genotype is C;C: 1.3x risk

Gene
ANAPC4
Location
Chr 425,415,622 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad1.3x riskTypical · 0.034% of people
  2. C;TNot ratednormalTypical · 0.047% of people
  3. T;TNot ratednormalTypical · 0.019% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 34% C;T 47% T;T 19%
  • European ancestry (Utah)C;C 18% C;T 49% T;T 33%
  • Han Chinese (Beijing)C;C 46% C;T 47% T;T 7%
  • Japanese (Tokyo)C;C 45% C;T 43% T;T 12%
  • Yoruba (Nigeria)C;C 31% C;T 49% T;T 20%
  • African ancestry (Southwest US)C;C 39% C;T 39% T;T 23%
  • Chinese (Denver)C;C 51% C;T 39% T;T 10%
  • Gujarati IndianC;C 34% C;T 51% T;T 15%
  • Luhya (Kenya)C;C 37% C;T 51% T;T 12%
  • Mexican ancestry (Los Angeles)C;C 18% C;T 53% T;T 30%
  • Maasai (Kenya)C;C 28% C;T 50% T;T 23%
  • TuscanC;C 28% C;T 46% T;T 27%

Conditions, medicines and genes

Other ANAPC4 SNPs

All ANAPC4 SNPs

Notes

From SNPedia

Notes

rs3816587 has been reported in a large study to be associated with rheumatoid arthritis. The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 0.91 (CI 0.80-1.04), and for homozygotes, 1.35 (CI 1.14-1.59).

Source and license

Adapted from rs3816587 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.