rs6427528

A SNP in the CD84 gene on chromosome 1. Its most notable genotype is A;A: for rheumatoid arthritis patients, better response to etanercept treatment

Gene
CD84
Location
Chr 1160,546,518 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
20%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodfor rheumatoid arthritis patients, better response to etanercept treatmentMinor · 1.56% of people
  2. A;GGoodfor rheumatoid arthritis patients, better response to etanercept treatmentMinor · 1.525% of people
  3. G;GGoodcommonTypical · 0.069% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 6% A;G 25% G;G 69%
  • European ancestry (Utah)A;A 0% A;G 11% G;G 89%
  • Han Chinese (Beijing)A;A 2% A;G 18% G;G 80%
  • Japanese (Tokyo)A;A 0% A;G 16% G;G 84%
  • Yoruba (Nigeria)A;A 23% A;G 55% G;G 23%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs6427528 is a SNP in the chromosome 1q23 region apparently located near enough to the CD84 locus to affect it's expression. A GWAS study of 2,700+ rheumatoid arthritis (RA) patients treated with one of three anti-TNF drugs found that rs6427528(A) carriers had higher CD84 expression and responded better to etanercept treatment. The effect was statistically significant but not that large in magnitude, totaling 2.6% of the variance in response to etanercept treatment. The result was seen in European (Caucasian) patients, but perhaps due to small patient numbers, was not statistically supported in Japanese patients.

Source and license

Adapted from rs6427528 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.