rs12212067

A SNP in the FOXO3 gene on chromosome 6. Its most notable genotype is G;G: Lower inflammatory response

Gene
FOXO3
Location
Chr 6108,659,993 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
13%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedLower inflammatory responseMinor · 1.54% of people
  2. G;TNot ratedLower inflammatory responseMinor · 1.524% of people
  3. T;TNot ratedGreater inflammatory responseMinor · 1.572% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageG;G 4% G;T 24% T;T 72%
  • European ancestry (Utah)G;G <1% G;T 14% T;T 85%
  • Han Chinese (Beijing)G;G 2% G;T 15% T;T 82%
  • Japanese (Tokyo)G;G <1% G;T 20% T;T 80%
  • Yoruba (Nigeria)G;G 5% G;T 31% T;T 64%
  • African ancestry (Southwest US)G;G 7% G;T 25% T;T 68%
  • Chinese (Denver)G;G 4% G;T 23% T;T 73%
  • Gujarati IndianG;G 1% G;T 16% T;T 83%
  • Luhya (Kenya)G;G 6% G;T 37% T;T 57%
  • Maasai (Kenya)G;G 7% G;T 38% T;T 55%
  • TuscanG;G 3% G;T 22% T;T 75%

Conditions, medicines and genes

Other FOXO3 SNPs

All FOXO3 SNPs

Notes

From SNPedia

Show notes, about 290 words

rs12212067 is a noncoding SNP in the FOXO3A gene. This gene encodes the FOXO3 protein, a member of the forkhead box O family of transcription factors. These proteins are expressed in many cell types, with roles in cell-cycle control, metabolism, regulatory T cell development and apoptosis. It's role in cytokine production appears to be the key factor in this SNP's association with disease prognosis (but, interestingly, no role in disease susceptibility has been found to date). rs12212067(G), the minor allele, is connected to the downregulation of TNF and several other proinflammatory cytokines in response to various antigens, and, the upregulation of IL10, a cytokine associated with anti-inflammatory effects. As elucidated in the cited study, this appears to explain the better outcomes for rs12212067(G) carriers of treatment for two auto-immune disorders, rheumatoid arthritis and Crohn's disease. As might be predicted for an infectious disease relying on an upregulated inflammatory response (which isn't happening as much with these carriers), this also leads to worse outcomes for carriers afflicted with malaria.; More recently, a different group of researchers have reported that, at least in the patients they studied, rs12212067 is a far weaker predictor of the clinical outcome for Crohn's disease patients than is rs2066847, a SNP in the NOD2 gene.

G;G

Associated with worse outcomes for malaria patients, but better outcomes for rheumatoid arthritis and Crohn's disease patients.

G;T

Associated with worse outcomes for malaria patients, but better outcomes for rheumatoid arthritis and Crohn's disease patients.

T;T

Associated with better outcomes for malaria patients, but worse outcomes for rheumatoid arthritis and Crohn's disease patients.

Source and license

Adapted from rs12212067 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.