rs1935949

A SNP in the FOXO3 gene on chromosome 6. Its most notable genotype is A;A: 1.46 OR for reaching "exceptional longevity"

Gene
FOXO3
Location
Chr 6108,678,084 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
42%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GNot ratedReferenceWorth knowing · 2.035% of people
  2. A;GGood1.27X likelihood of "exceptional longevity"Worth knowing · 2.034% of people
  3. A;AMost notableGood1.46 OR for reaching "exceptional longevity"Worth knowing · 2.531% of people

SNPedia records rs1935949 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 35% A;G 34% A;A 31%
  • European ancestry (Utah)G;G 54% A;G 38% A;A 8%
  • Han Chinese (Beijing)G;G 69% A;G 24% A;A 7%
  • Japanese (Tokyo)G;G 64% A;G 34% A;A 3%
  • Yoruba (Nigeria)G;G 0% A;G 11% A;A 89%
  • African ancestry (Southwest US)G;G 9% A;G 18% A;A 74%
  • Chinese (Denver)G;G 58% A;G 36% A;A 6%
  • Gujarati IndianG;G 26% A;G 51% A;A 24%
  • Luhya (Kenya)G;G 4% A;G 28% A;A 69%
  • Mexican ancestry (Los Angeles)G;G 45% A;G 46% A;A 9%
  • Maasai (Kenya)G;G 14% A;G 45% A;A 42%
  • TuscanG;G 41% A;G 45% A;A 14%

Conditions, medicines and genes

Other FOXO3 SNPs

All FOXO3 SNPs

Notes

From SNPedia

Notes

rs1935949 is an intronic SNP in the FOXO3 gene. rs1935949 demonstrated a significant association with longevity but only among women (odds ratio 1.35, CI:1.15-1.57, adjusted p=0.0093).

G;G

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652804/

A;G

According to https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652804/ table 4.

A;A

According to https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652804/ table 4.

Source and license

Adapted from rs1935949 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.