rs2802288

A SNP in the FOXO3 gene on chromosome 6. Its most notable genotype is A;A: longer lifespan

Gene
FOXO3
Location
Chr 6108,575,012 (GRCh38)
Highest magnitude
2.4Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
45%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodlonger lifespanWorth knowing · 2.431% of people
  2. A;GNot ratedNo summary available.Typical · 0.039% of people
  3. G;GNot ratednormalTypical · 0.030% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 31% A;G 39% G;G 30%
  • European ancestry (Utah)A;A 14% A;G 44% G;G 42%
  • Han Chinese (Beijing)A;A 7% A;G 29% G;G 65%
  • Japanese (Tokyo)A;A 4% A;G 42% G;G 54%
  • Yoruba (Nigeria)A;A 69% A;G 28% G;G 3%
  • African ancestry (Southwest US)A;A 60% A;G 30% G;G 11%
  • Chinese (Denver)A;A 6% A;G 40% G;G 53%
  • Gujarati IndianA;A 31% A;G 52% G;G 18%
  • Luhya (Kenya)A;A 59% A;G 33% G;G 8%
  • Mexican ancestry (Los Angeles)A;A 16% A;G 40% G;G 44%
  • Maasai (Kenya)A;A 55% A;G 37% G;G 8%
  • TuscanA;A 25% A;G 50% G;G 26%

Conditions, medicines and genes

Other FOXO3 SNPs

All FOXO3 SNPs

Notes

From SNPedia

Notes

23andMe blog longevity rs2802288(A) increased the odds of living to 100 by 1.5x. rs2802288 is located very close to rs2802292 which was previously reported to have a similar effect.

Source and license

Adapted from rs2802288 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.