rs2802292

A SNP in the FOXO3 gene on chromosome 6. Its most notable genotype is G;G: 1.5x~2.7x more likely to live to 100.

Gene
FOXO3
Location
Chr 6108,587,315 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
45%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableGood1.5x~2.7x more likely to live to 100.Worth knowing · 2.524% of people
  2. G;TGoodOne copy of a longevity gene. Slightly increased lifespan.Worth knowing · 2.037% of people
  3. T;TBadLess likely to live to 100.Worth knowing · 2.539% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 24% G;T 37% T;T 39%
  • European ancestry (Utah)G;G 20% G;T 45% T;T 34%
  • Han Chinese (Beijing)G;G 4% G;T 29% T;T 67%
  • Japanese (Tokyo)G;G 2% G;T 43% T;T 55%
  • Yoruba (Nigeria)G;G 68% G;T 30% T;T 2%

Conditions, medicines and genes

Other FOXO3 SNPs

All FOXO3 SNPs

Notes

From SNPedia

Show notes, about 370 words

A study of 5 genes in 3,741 Japanese men, some of whom lived significantly longer than average (centarians), concluded that the FOXO3 gene (also known as FOXO3A) harbors several SNPs linked to longevity, including this SNP, rs2802292, as well as rs2764264 and rs13217795. The odds ratio for rs2802292(G;G) vs (T;T) carriers was 2.75 (p = 0.00009; adjusted p = 0.00135). It is not known yet if this correlation is specific to Japanese males. This is discussed extensively at geneticfuture as a longevity snp. *(T) shorter lifespan *(G) longer lifespan Quoted from the geneticfuture article: "No-one should consider this association to be definitive until it's been replicated in independent cohorts. Secondly, the effects of this variant are likely to differ between groups. According to the HapMap database the frequency of the "die early" (T) version of the variant varies substantially between populations: it's around 76% in Japanese, slightly more common (81%) in Chinese, less common (58%) in Europeans, and quite rare (17%) in West Africans. Given that the Japanese have the highest life expectancy of any of these populations, this is a counter-intuitive result, which reinforces the fact that there are many genes and other factors influencing variation in longevity." 23andMe blog longevity rs2802288(A) increased the odds of living to 100 by 1.5x. rs2802288 is located very close to rs2802292 which was previously reported to have a similar effect. A study of males from the Southern Italian Centenarian Study also replicated the association between rs2802288, a proxy of rs2802292, and longevity, with an odds ratio of 1.51 (CI: 1.15-1.98, p = 0.003).

G;G

This is the best version of the well known longevity gene FOXO3. It greatly improves the odds of living to 100. It seems to improve insulin sensitivity, and reduce oxidative stress, among other things.

G;T

This is a well known longevity gene, FOXO3, although only one of your copies is the good version. It seems to improve insulin sensitivity, and decrease oxidative stress, among other things.

T;T

Unfortunately, this version of FOXO3 has reduced longevity. It has lower insulin sensitivity, increased oxidative stress, and increased risk of diabetes and heart disease.

Source and license

Adapted from rs2802292 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.