rs2764264

A SNP in the FOXO3 gene on chromosome 6. Its most notable genotype is C;C: greater odds of living to 95

Gene
FOXO3
Location
Chr 6108,613,258 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
44%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodgreater odds of living to 95Worth knowing · 2.033% of people

On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 33%
  • European ancestry (Utah)C;C 9%
  • Han Chinese (Beijing)C;C 7%
  • Japanese (Tokyo)C;C 4%
  • Yoruba (Nigeria)C;C 91%
  • African ancestry (Southwest US)C;C 70%
  • Chinese (Denver)C;C 7%
  • Gujarati IndianC;C 25%
  • Luhya (Kenya)C;C 73%
  • Mexican ancestry (Los Angeles)C;C 10%
  • Maasai (Kenya)C;C 50%
  • TuscanC;C 18%

Conditions, medicines and genes

Other FOXO3 SNPs

All FOXO3 SNPs

Notes

From SNPedia

Notes

(C;C) greater odds of longevity Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study.

Source and license

Adapted from rs2764264 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.