rs3817964
A SNP in the LOC101929163 gene on chromosome 6. Its most notable genotype is T;T: normal
- Gene
- LOC101929163
- Location
- Chr 632,400,220 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 6%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableGoodnormal
- A;TNot ratedpossibly at 4x higher risk of rheumatoid arthritis
- A;ANot rated6x higher risk of rheumatoid arthritis
SNPedia records rs3817964 on the minus strand: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageT;T 91% A;T 9% A;A <1%
- European ancestry (Utah)T;T 83% A;T 16% A;A 2%
- Han Chinese (Beijing)T;T 91% A;T 9% A;A 0%
- Japanese (Tokyo)T;T 91% A;T 9% A;A 0%
- Yoruba (Nigeria)T;T 100% A;T 0% A;A 0%
Related
Conditions, medicines and genes
Other LOC101929163 SNPs
- rs3129934T;T3.3x increased risk for multiple sclerosisWorth knowing
- rs498422G;G>1.42x slightly higher risk for infertility in Chinese menMinor
- rs10947262C;C1.3x increased risk for osteoarthritisMinor
- rs1980493T;Tcommon on affy axiom dataTypical
- rs2076530T;T2x risk for sarcoidosisTypical
- rs2395148G;Gcommon in complete genomicsTypical
- rs3117103A;Acommon on affy axiom dataTypical
- rs3130340T;TNo summary available.Typical
Notes
From SNPedia
Show notes, about 140 words
This SNP, along with SNPs rs6910071 and rs660895, is a tag SNP for the HLA-DRB1*0401 allele. The HLA-DRB1*0401 allele has been associated with higher risk for rheumatoid arthritis, and in particular, rheumatoid vasculitis. The association is seen particularly for individuals carrying two copies of, i.e. homozygous for, the allele. The reported odds ratio for rs3817964(T;T) homozygotes is 6.2 (CI: 1.01 - 37.9). The risk for rheumatoid arthritis may be higher for individuals carrying one copy (one "dose") of the HLA-DRB1*0401 allele, if they also carry a different HLA-DRB1 risk allele. In particular, *0401/*0404 individuals are reported to have an odds ratio for rheumatoid vasculitis of 4.1 (CI: 1.1 - 16.2), and *0401/*0101 individuals have an odds ratio of 4.0 (CI: 1.4 - 11.6).
A;A
appears to be common on the 23andMe platform
Source and license
Adapted from rs3817964 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.