rs498422
A SNP in the LOC101929163 gene on chromosome 6. Its most notable genotype is G;G: >1.42x slightly higher risk for infertility in Chinese men
- Gene
- LOC101929163
- Location
- Chr 632,318,984 (GRCh38)
- Highest magnitude
- 1.4Minor
- Tested on
- 23andMe, FamilyTreeDNA
- Minor allele frequency
- 15%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TGoodnormal risk for infertility in Chinese men
- G;TBad1.42x higher risk for infertility in Chinese men
- G;GMost notableBad>1.42x slightly higher risk for infertility in Chinese men
SNPedia records rs498422 on the minus strand: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 65% G;T 30% G;G 5%
- European ancestry (Utah)T;T 91% G;T 9% G;G 0%
- Han Chinese (Beijing)T;T 67% G;T 31% G;G 2%
- Japanese (Tokyo)T;T 56% G;T 39% G;G 5%
- Yoruba (Nigeria)T;T 41% G;T 48% G;G 12%
- African ancestry (Southwest US)T;T 42% G;T 46% G;G 12%
- Chinese (Denver)T;T 82% G;T 18% G;G 0%
- Gujarati IndianT;T 75% G;T 25% G;G 0%
- Luhya (Kenya)T;T 41% G;T 44% G;G 16%
- Mexican ancestry (Los Angeles)T;T 83% G;T 17% G;G 0%
- Maasai (Kenya)T;T 55% G;T 37% G;G 9%
- TuscanT;T 82% G;T 17% G;G 1%
Related
Conditions, medicines and genes
Other LOC101929163 SNPs
- rs3129934T;T3.3x increased risk for multiple sclerosisWorth knowing
- rs10947262C;C1.3x increased risk for osteoarthritisMinor
- rs1980493T;Tcommon on affy axiom dataTypical
- rs2076530T;T2x risk for sarcoidosisTypical
- rs2395148G;Gcommon in complete genomicsTypical
- rs3117103A;Acommon on affy axiom dataTypical
- rs3130340T;TNo summary available.Typical
- rs3763305G;Gcommon in complete genomicsTypical
Notes
From SNPedia
Notes
rs3129878 is a SNP on chromosome 6, within a gene known as chromosomal open reading frame 10 (C6orf10). It has been associated with slightly (~40%) higher risk for azoospermia (lack of sperm) and thus male infertility in Chinese but not Japanese men.
G;T
A 2012 study of Han Chinese men showed slightly increased risk (odds ratio 1.42) for nonobstructive azoospermia (very low sperm count) and thus infertility for the rarer rs498422(C) SNP.
G;G
A 2012 study of Han Chinese men showed slightly increased risk (odds ratio 1.42) for nonobstructive azoospermia (very low sperm count) and thus infertility for the rarer rs498422(C) SNP.
Source and license
Adapted from rs498422 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.