rs498422(G;T)

1.42x higher risk for infertility in Chinese men

Magnitude
1.3Minor
Repute
Bad
Frequency
30%Average of 11 populations
On SNPedia
rs498422(A;C)Minus strand
Gene
LOC101929163

Frequency

Share of people with G;T in each HapMap population.

  • Yoruba (Nigeria)48%
  • African ancestry (Southwest US)46%
  • Luhya (Kenya)44%
  • Japanese (Tokyo)39%
  • Maasai (Kenya)37%
  • Han Chinese (Beijing)31%
  • Gujarati Indian25%
  • Chinese (Denver)18%
  • Mexican ancestry (Los Angeles)17%
  • Tuscan17%
  • European ancestry (Utah)9%

Other genotypes of rs498422

  1. T;TGoodnormal risk for infertility in Chinese menTypical · 0.065% of people
  2. G;GMost notableBad>1.42x slightly higher risk for infertility in Chinese menMinor · 1.45% of people

All about rs498422

Notes

From SNPedia

A 2012 study of Han Chinese men showed slightly increased risk (odds ratio 1.42) for nonobstructive azoospermia (very low sperm count) and thus infertility for the rarer rs498422(C) SNP.

Source and license

Adapted from rs498422(A;C) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.