rs10947262

A SNP in the LOC101929163 gene on chromosome 6. Its most notable genotype is C;C: 1.3x increased risk for osteoarthritis

Gene
LOC101929163
Location
Chr 632,405,535 (GRCh38)
Highest magnitude
1.3Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
17%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad1.3x increased risk for osteoarthritisMinor · 1.369% of people
  2. T;TNot ratedNo summary available.Typical · 0.04% of people

On SNPedia: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 69% T;T 4%
  • European ancestry (Utah)C;C 89% T;T 0%
  • Han Chinese (Beijing)C;C 51% T;T 8%
  • Japanese (Tokyo)C;C 34% T;T 19%
  • Yoruba (Nigeria)C;C 74% T;T 3%
  • African ancestry (Southwest US)C;C 79% T;T 2%
  • Chinese (Denver)C;C 60% T;T 6%
  • Gujarati IndianC;C 70% T;T 3%
  • Luhya (Kenya)C;C 77% T;T 3%
  • Mexican ancestry (Los Angeles)C;C 64% T;T 3%
  • Maasai (Kenya)C;C 85% T;T 0%
  • TuscanC;C 80% T;T 1%

Conditions, medicines and genes

Other LOC101929163 SNPs

All LOC101929163 SNPs

Notes

From SNPedia

Notes

rs10947262(C) was found to be associated with increased risk for osteoarthritis among Japanese and Europeans, with an odds ratio of 1.32 (CI: 1.19-1.46, combined p = 6.73×10e-8). This SNP is also in linkage disequilibrium with rs7775228, which was found to be associated in Japanese with osteoarthritis.

Source and license

Adapted from rs10947262 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.