rs7574865(T;T)

1.69x risk of rheumatoid arthritis; 2.4x risk of SLE; 2.28x risk of Sjögren's syndrome; increased risk of type-1 diabetes; and increased risk of primary biliary cirrhosis.

Magnitude
3.5Important
Repute
Bad
Frequency
8%Average of 11 populations
On SNPedia
rs7574865(T;T)
Gene
STAT4

Frequency

Share of people with T;T in each HapMap population.

  • Mexican ancestry (Los Angeles)18%
  • Japanese (Tokyo)14%
  • Chinese (Denver)12%
  • Han Chinese (Beijing)12%
  • Gujarati Indian9%
  • Tuscan7%
  • European ancestry (Utah)6%
  • African ancestry (Southwest US)4%
  • Yoruba (Nigeria)3%
  • Luhya (Kenya)3%
  • Maasai (Kenya)1%

Other genotypes of rs7574865

  1. G;GGoodnormal risk of rheumatoid arthritis, SLE, Sjögren's syndrome, type-1 diabetes, and primary biliary cirrhosis.Minor · 1.056% of people
  2. G;TBad1.3x risk of rheumatoid arthritis; 1.55x risk of SLE; 1.42x risk of Sjögren's syndrome; increased risk of type-1 diabetes; and increased risk of primary biliary cirrhosis.Worth knowing · 2.536% of people

All about rs7574865

Source and license

Adapted from rs7574865(T;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.