Type-1 diabetes

61 SNPs linked to Type-1 diabetes across 37 genes, 14 with a genotype of magnitude 2 or higher.

Type: Condition
SNPs: 61
Notable: 14Magnitude 2 or higher
Well documented: 50
Genes: 37

Linked SNPs

Every genotype, as shown in 23andMe and AncestryDNA files.

rs572115942PHKG2Very important
- A;GIn type-1 diabetics (only), Mauriac syndrome predictedBad
- G;Gcommon/normalGood
rs7574865STAT4Important
- G;Gnormal risk of rheumatoid arthritis, SLE, Sjögren's syndrome, type-1 diabetes, and primary biliary cirrhosis.Good
- G;T1.3x risk of rheumatoid arthritis; 1.55x risk of SLE; 1.42x risk of Sjögren's syndrome; increased risk of type-1 diabetes; and increased risk of primary biliary cirrhosis.Bad
- T;T1.69x risk of rheumatoid arthritis; 2.4x risk of SLE; 2.28x risk of Sjögren's syndrome; increased risk of type-1 diabetes; and increased risk of primary biliary cirrhosis.Bad
rs2476601PTPN22Important
- A;A2x risk of rheumatoid arthritis and other autoimmune diseasesBad
- A;GIncreased Risk of Multiple Autoimmune DisordersBad
- G;GNormal risk for autoimmune disordersGood
rs6679677RSBN1Important
- A;A5.2x risk for T1D; 3.3x for RABad
- A;C1.8x risk for T1D; 2x risk for RABad
- C;CnormalGood
rs9272346HLA-DQA1Important
- A;A18.5x risk for type-1 diabetesBad
- A;G5.49x risk of type-1 diabetesBad
- G;GNo increased risk of Type 1 Diabetes on an important SNPGood
rs13266634SLC30A8Important
- C;Cincreased risk for type-2 diabetesBad
- C;Tincreased risk for type-2 diabetesBad
- T;TNormal risk for type-2 diabetesGood
rs5219KCNJ11Worth knowing
- C;CnormalGood
- C;T1.3x increased risk for type-2 diabetesBad
- T;T2.5x increased risk for type-2 diabetesBad
rs17696736NAA25Worth knowing
- A;AnormalNot rated
- A;G1.34x risk of type-1 diabetesBad
- G;G1.94x risk of type-1 diabetesBad
- T;TNo summary available.Not rated
rs3129934LOC101929163Worth knowing
- C;CNormal lower risk of Multiple Sclerosis.Good
- C;TIncreased risk of Multiple Sclerosis.Bad
- T;T3.3x increased risk for multiple sclerosisBad
rs763361CD226Worth knowing
- C;CNormal risk for multiple autoimmune diseasesGood
- C;TSlightly increased risk for multiple autoimmune diseases, such as type-1 diabetesBad
- T;TIncreased risk for multiple autoimmune diseasesBad
rs1893217PTPN2Worth knowing
- G;GSomewhat increased (~2x) risk for Crohn's diseaseBad
- A;GSlightly increased (1.4x) risk for Crohn's diseaseBad
- A;Acommon/normalGood
rs2070600AGERWorth knowing
- T;T2x higher retinopathy risk in diabetics; 1.5x increased overall risk for gastric cancerBad
- C;T1.5x increased risk for gastric cancerBad
- C;CnormalGood
rs2542151PTPN2Worth knowing
- G;G2x risk for Crohn's; 1.6x for T1DBad
- G;T1.3x risk for Crohn's; 1.3x for T1DBad
- T;TnormalGood
rs11171739ERBB3Worth knowing
- A;ANo summary available.Not rated
- C;C1.75x risk of developing Type-1 diabetesBad
- C;T1.34x risk of developing Type-1 diabetesBad
- T;TNormal risk of developing Type-1 diabetesGood
rs2488457PTPN22Minor
- G;Gcommon/normalGood
- C;GSlightly increased (~1.5x) risk for certain autoimmune diseases in some populationsBad
- C;CSlightly increased (~1.7x) risk for certain autoimmune diseases in some populationsBad
rs3087243CTLA4Minor
- A;ANormal risk for auto-immune diseasesGood
- A;Gincreased risk for auto-immune diseasesBad
- G;GIncreased risk for autoimmune diseasesBad
rs3184504SH2B3Minor
- C;CnormalGood
- C;TSlightly increased risk for celiac diseaseBad
- T;Tslightly (1.4x) increased risk for celiac diseaseBad
rs7454108Minor
- C;CHomozygous for HLA-DQ8 haplotypeBad
- C;TSingle HLA-DQ8 haplotypeBad
- T;Tcommon in complete genomicsGood
rs2104286IL2RAMinor
- T;T1.7x risk for RA; 1.6X for T1D; also MS?Bad
- C;T1.4x risk for RA; 1.3x for T1D; also MS?Bad
- C;Cprotective minor allele, slightly reducing risk for MS & RAGood
rs4496877NOS3Minor
- G;GNo summary available.Not rated
- G;TFor type-1 diabetics, 1.3x increased nephropathy riskNot rated
- T;TFor type-1 diabetics, 1.6x increased nephropathy riskBad
rs3194051IL7RMinor
- A;A>1.1x risk of type-1 diabetesBad
- A;G1.12x risk of type-1 diabetesBad
- G;GnormalGood
rs6932590TRNAV27Minor
- C;Crare but normalNot rated
- C;T1.1x increased risk for schizophreniaBad
- T;T1.1x increased risk for schizophreniaBad
rs689INSTypical
- A;Acommon in clinvarGood
rs5215KCNJ11Typical
- C;Ccommon in clinvarGood
rs5498LOC105372272Typical
- A;AnormalNot rated
- A;G0.6x decreased risk for diabetic nephropathy in females with type-1 diabetes; 1.9x increased malaria riskNot rated
- G;G0.6x decreased risk for diabetic nephropathy in females with type-1 diabetes; 1.9x increased malaria riskNot rated
rs213950CFTRTypical
- A;Avery slight (1.1x) increase in type-1 diabetes riskNot rated
- A;Gvery slight (1.1x) increase in type-1 diabetes riskNot rated
- G;GnormalGood
rs439121Typical
- A;Acommon in complete genomicsGood
rs725613CLEC16ATypical
- T;T1.2x increased type-1 diabetes risk; 1.2x increased multiple sclerosis riskBad
- G;T1.2x increased type-1 diabetes risk; 1.2x increased multiple sclerosis riskBad
- G;GnormalNot rated
rs1982073TGFB1Typical
- G;Grisk genotype for several disordersNot rated
- A;Grisk genotype for several disordersNot rated
- A;Arisk genotype for several disordersNot rated
rs1990760IFIH1Typical
- C;Ccommon in clinvarGood
rs2040410Typical
- C;Ccommon/normalGood
rs2076530LOC101929163Typical
- T;T2x risk for sarcoidosisBad
- C;Tincreased risk for sarcoidosisBad
- C;CnormalNot rated
rs2157678TRIM10Typical
- G;Gcommon on affy axiom dataGood
rs2292239ERBB3Typical
- T;T1.7x riskNot rated
- G;T1.3x riskBad
- G;GnormalNot rated
- A;ANo summary available.Not rated
rs2296336ITPR3Typical
- G;G2.9x risk of type-1 diabetesBad
- C;G1.3x risk of type-1 diabetesBad
- C;CnormalGood
rs2544677Typical
- G;GnormalNot rated
- C;G1.3x risk of type-1 diabetesBad
- C;C1.7x risk of type-1 diabetesBad
rs2639703ENAHTypical
- A;ANo summary available.Not rated
- C;C1.6x riskNot rated
- C;T1.1x riskNot rated
- T;TnormalNot rated
rs3094628HCG18Typical
- G;Gcommon on affy axiom dataGood
rs3130352UBQLN1PTypical
- C;Ccommon on affy axiom dataGood
rs3130380HCG18Typical
- G;Gcommon on affy axiom dataGood
rs3804100TLR2Typical
- C;Csomwhat increased risk for type-1 diabetes and allergic asthmaNot rated
- C;Tsomewhat increased risk for type-1 diabetes and allergic asthmaNot rated
- T;TnormalGood
rs6822844Typical
- G;Gcommon on affy axiom dataGood
rs11052552LOC105369652Typical
- G;G1.4x risk of type-1 diabetesBad
- G;T1.5x risk of type-1 diabetesBad
- T;TnormalNot rated
rs12094543ZMYM4Typical
- A;A>1.3x risk of type I diabetesBad
- A;G1.3x risk of type I diabetesBad
- G;GnormalNot rated
rs12150220NLRP1Typical
- A;Aslightly increased risk for several autoimmune diseasesBad
- A;Tslightly increased risk for several autoimmune diseasesBad
- T;TnormalNot rated
rs12708716CLEC16ATypical
- A;A1.6x risk of type-1 diabetesBad
- A;G1.2x risk of type-1 diabetesBad
- G;GnormalNot rated
rs12722489IL2RATypical
- C;Ta slight increase in risk of developing multiple sclerosisBad
- C;Ca slight increase in risk of developing multiple sclerosisBad
rs13293564UNC13BTypical
- G;G1.63x increased nephropathy risk among type-1 diabeticsNot rated
- G;TnormalNot rated
- T;TnormalNot rated
rs17166496FSTL4Typical
- C;C1.1x risk for type-1 diabetesBad
- C;G0.8x risk for type-1 diabetesBad
- G;GnormalNot rated
rs17388568ADAD1Typical
- A;A1.6x risk of type-1 diabetesBad
- A;G1.3x risk of type-1 diabetesBad
- G;GnormalNot rated

Genes

CLEC16A2
ERBB32
HCG182
IL2RA2
KCNJ112
LOC1019291632
PTPN22
PTPN222
ADAD11
AGER1
CD2261
CFTR1

Genosets

Gs121DR3/4-DQ8 individual at high risk for type-1 diabetesVery important
Gs117Risk of type-1 diabetesVery important

Genosets combine several genotypes. Twofold checks them in your report.

Other SNPs

No notable genotype or detailed notes

Show 11 SNPs

rs706778
rs876498
rs910049
rs1129456
rs1445898
rs2259571
rs2281999
rs3741208
rs7202877
rs11571316
rs35667974

Source and license

Adapted from Type-1 diabetes on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.