Type-2 diabetes

124 SNPs linked to Type-2 diabetes across 50 genes, 26 with a genotype of magnitude 2 or higher.

Type: Condition
SNPs: 124
Notable: 26Magnitude 2 or higher
Well documented: 78
Genes: 50

Linked SNPs

Every genotype, as shown in 23andMe and AncestryDNA files.

rs367643250DYRK1BVery important
- A;Gcausative for obesity, coronary artery disease, type-2 diabetes?Bad
- G;GcommonGood
rs7903146TCF7L2Important
- C;CNormal (lower) risk of Type 2 Diabetes and Gestational Diabetes.Good
- C;T1.4x increased risk for diabetes (and perhaps colon cancer).Bad
- T;T2x increased risk for Type-2 diabetesBad
rs10830963MTNR1BImportant
- C;Cnormal risk of Type-2 DiabetesGood
- C;Gincreased type-2 diabetes risk; higher gestational diabetes riskBad
- G;Gincreased type-2 diabetes risk; higher gestational diabetes riskBad
rs1042522TP53Important
- G;GLive 3 years longer. Chemotherapy is more effective.Good
- C;GSlightly increased lifespan?Good
- C;CCommon variant. Slightly shorter lifespan.Bad
rs1121980FTOImportant
- G;GaverageGood
- A;GSlight increase (1.67x) in risk for obesityBad
- A;AModerate increase (2.76x) in risk for obesityBad
rs1799884GCKImportant
- T;T2.7x increased risk for Type 2 Diabetes. Mothers have babies 54g heavier.Bad
- C;T1.3x increased risk for Type 2 Diabetes. Mothers have babies 27g heavier.Bad
- C;CMothers have typical Birth-Weight babies. Slightly lower risk of Type 2 Diabetes.Good
rs1801282PPARGImportant
- C;Cnormal fat metabolism; common in clinvarGood
- C;GUnconfirmed higher risk of cardiovascular disease with high saturated fat dietBad
- G;GUnconfirmed higher risk of cardiovascular disease with high saturated fat dietBad
rs7754840CDKAL1Important
- C;C1.3x increased risk for type-2 diabetesBad
- C;G1.3x increased risk for type-2 diabetesBad
- G;GnormalGood
rs9939609FTOImportant
- A;Aobesity risk and 1.6x risk for T2DBad
- A;T1.3x risk for T2D; obesity riskBad
- T;Tlower risk of obesity and Type-2 diabetesGood
rs13266634SLC30A8Important
- C;Cincreased risk for type-2 diabetesBad
- C;Tincreased risk for type-2 diabetesBad
- T;TNormal risk for type-2 diabetesGood
rs5219KCNJ11Worth knowing
- C;CnormalGood
- C;T1.3x increased risk for type-2 diabetesBad
- T;T2.5x increased risk for type-2 diabetesBad
rs17782313MC4RWorth knowing
- C;Cadults likely to be 0.44 BMI units higherBad
- C;Tadults likely to be 0.22 BMI units higherBad
- T;TnormalGood
rs1859962CASC17Worth knowing
- G;G1.28x increased risk for prostate cancerBad
- G;Tnormal riskGood
- T;Tnormal riskGood
rs3816873MTTPWorth knowing
- C;Creduced risk of type-2 diabetesGood
- C;TNo summary available.Not rated
- T;TNo summary available.Good
rs12255372TCF7L2Worth knowing
- G;GnormalGood
- G;T1.3x increased type-2 diabetes riskBad
- T;Tslight increases (~1.5x) in risk for type-2 diabetes and possibly breast cancer and aggressive prostate cancerBad
rs268LPLWorth knowing
- A;Acommon in clinvarGood
- A;G3X increased risk for venous thromboembolismBad
- G;G3X+ increased risk for venous thromboembolismBad
rs4402960IGF2BP2Worth knowing
- G;GnormalGood
- G;T1.2x increased risk for type-2 diabetes, ~1x risk for gestational diabetesBad
- T;T1.2x increased risk for type-2 diabetes, 1.5x risk for gestational diabetesBad
rs4430796HNF1BWorth knowing
- A;A1.38x increased risk for prostate cancerBad
- A;Gnormal riskNot rated
- G;Gnormal riskNot rated
rs10811661Worth knowing
- C;CnormalGood
- C;T1.2x increased risk for type-2 diabetesBad
- T;T1.2x increased risk for type-2 diabetesBad
rs358806Worth knowing
- A;ANormal risk of developing Type-2 diabetesGood
- A;C0.86x increased risk of developing Type-2 diabetesBad
- C;C1.78x increased risk of developing Type-2 diabetesBad
rs1143699PTPRSWorth knowing
- G;GIn men, 2.19x risk of type 2 diabetesBad
rs1800795IL6Worth knowing
- C;Cless IL6; certain risks, see detailsBad
- C;Gcomplex; see detailsNot rated
- G;Gmore IL6; certain risks, see detailsBad
rs4506565TCF7L2Worth knowing
- A;Acommon/normalGood
- A;T1.4x increased risk for type-2 diabetesBad
- T;T1.9x increased risk for type-2 diabetesBad
rs7923837Worth knowing
- A;Anormal risk for T2DGood
- A;G1.6x risk for T2DBad
- G;G3.2x risk for T2DBad
rs4807015PTPRSMinor
- C;C>1.74x risk of type 2 diabetesBad
- C;T1.74x risk of type 2 diabetesBad
- T;TNo increased risk of Type 2 diabetesNot rated
rs9402571SGK1Minor
- G;G0.85x decreased risk for type-2 diabetesGood
- G;Tslightly decreased risk for type-2 diabetesGood
- T;TnormalNot rated
rs1978237PTPRSMinor
- C;C>1.59x risk of Type 2 diabetesBad
- C;G1.59x risk of Type 2 diabetesBad
- G;GNo increased risk of Type 2 diabetesNot rated
rs1137101LEPRMinor
- A;Acommon in clinvarGood
- A;GSlight increase in obesity and T2DM riskBad
- G;GSlight increase in obesity and T2DM riskBad
rs2233580PAX4Minor
- C;TReported to slightly increase (1.5x) risk for T2D in AsiansBad
- C;Ccommon in clinvarGood
rs117767867SLC16A11Minor
- C;CcommonGood
- C;T1.25x risk for type 2 diabetesBad
- T;T1.5x risk for type 2 diabetesBad
rs2237897KCNQ1Minor
- C;CcommonNot rated
- C;T1.2x increased risk for diabetic nephropathy in some populationsNot rated
- T;T1.4x increased risk for diabetic nephropathy in some populationsNot rated
rs8050136FTOMinor
- A;A1.4x increased risk for T2D in some populationsBad
- A;C1.2x increased risk for T2D in some populationsBad
- C;CnormalNot rated
rs2295490TRIB3Minor
- A;AnormalGood
- A;G1.32x increased risk of early-onset type-2 diabetesBad
- G;G1.32x increased risk of early-onset type-2 diabetesBad
rs5370EDN1Minor
- G;GcommonNot rated
- G;Tpossibly lower HDL cholesterol in womenBad
- T;Tpossibly lower HDL cholesterol in womenBad
rs28647808ADAMTS13Minor
- C;Camong diabetic patients, somewhat lower risk for complications but also lower response to therapyNot rated
- C;Gamong diabetic patients, somewhat higher risk for complications but also better response to therapyNot rated
- G;Gamong diabetic patients, somewhat higher risk for complications but also better response to therapyNot rated
rs780094GCKRTypical
- T;Tmetabolic consequencesNot rated
- C;Tmetabolic consequencesNot rated
- C;CaverageNot rated
rs997509ENPP1Typical
- C;Ccommon in complete genomicsGood
- C;TNo summary available.Not rated
rs1042714ADRB2Typical
- C;CnormalGood
- C;Gcomplex; see details for increased risksNot rated
- G;Gcomplex; see details for increased risksNot rated
rs1111875Typical
- T;T1x normal risk of T2DNot rated
- C;T1.3x risk of type-2 diabetesNot rated
- C;C2.4x risk of type-2 diabetesNot rated
- A;ANo summary available.Not rated
rs1470579IGF2BP2Typical
- A;AnormalNot rated
- A;C1.2x increased risk for type-2 diabetesBad
- C;C1.2x increased risk for type-2 diabetesBad
rs1495377Typical
- G;GnormalGood
- C;G1.3x risk type-2 diabetesBad
- C;C1.5x risk type-2 diabetesBad
rs1528133RIC3Typical
- T;Tnormal riskGood
- G;Thigher body mass indexNot rated
- G;Ghigher body mass indexNot rated
- A;ANo summary available.Not rated
rs1535435AHI1Typical
- A;ANo summary available.Not rated
- A;GNo summary available.Not rated
- G;GNo summary available.Not rated
rs1889018SREBF1Typical
- G;GnormalNot rated
- A;G1.12x increased risk for T2DNot rated
- A;A1.12x increased risk for T2DNot rated
rs1982073TGFB1Typical
- G;Grisk genotype for several disordersNot rated
- A;Grisk genotype for several disordersNot rated
- A;Arisk genotype for several disordersNot rated
rs2077119AHSGTypical
- G;G0.91x decreased risk for T2DNot rated
- G;T0.91x decreased risk for T2DNot rated
- T;T1x normal riskNot rated
rs2197423PPARGTypical
- G;GNo summary available.Not rated
rs2209972MARK2P9Typical
- C;Chigher risk for PCOS?Not rated
- C;Thigher risk for PCOS?Not rated
- T;Tnormal riskNot rated
rs2237892KCNQ1Typical
- C;Ccommon in complete genomicsGood
rs2267668PPARDTypical
- A;ANo summary available.Not rated
rs2270031WNT5BTypical
- C;Ccommon in complete genomicsGood
rs2272382TUBTypical
- T;Tslightly higher body mass indexNot rated
- C;Tslightly higher body mass indexNot rated
- C;Ccommon/normalGood
rs2272383TUBTypical
- A;Anormal riskNot rated
- A;Ghigher body mass indexNot rated
- G;Ghigher body mass indexNot rated
rs2274924TRPM6Typical
- T;Tcommon in clinvarGood
rs2283228KCNQ1Typical
- A;Acommon in complete genomicsGood
rs2297508SREBF1Typical
- G;GnormalNot rated
- C;G1.08x increased risk for T2DNot rated
- C;C1.08x increased risk for T2DNot rated
rs2793831NOTCH2Typical
- T;Tcommon in complete genomicsGood
rs2930291CCDC33Typical
- G;G1.5x riskBad
- A;G1.3x riskNot rated
- A;AnormalNot rated
rs3750425TRPM6Typical
- C;Ccommon in clinvarGood
rs3802177SLC30A8Typical
- G;G1.16x increased risk for type-2 diabetesNot rated
- A;G1.16x increased risk for type-2 diabetesBad
- A;AnormalNot rated
rs4655595PDE4BTypical
- A;AnormalNot rated
- A;G1.4 riskNot rated
- G;G2.3 riskNot rated
rs4740283Typical
- A;ANo summary available.Not rated
rs6718526RBMS1Typical
- C;C1.9x risk of type-2 diabetesBad
- C;T1.5x riskBad
- T;TnormalNot rated
rs6802898PPARGTypical
- C;CNo summary available.Not rated
rs7501939HNF1BTypical
- C;TNo summary available.Not rated
rs7659604Typical
- C;C1.1x risk of type II diabetesBad
- C;T1.4x risk of type II diabetesBad
- T;TnormalGood
rs7756992CDKAL1Typical
- A;AnormalGood
- A;G1.3x increased risk for type-2 diabetesBad
- G;G1.3x increased risk for type-2 diabetesBad
rs9300039Typical
- A;Anormal riskGood
- A;C1.5x risk for T2DBad
- C;C>1.5x risk for T2DBad
rs9326506ZNF239Typical
- A;ANo summary available.Not rated
- A;C1.3x riskNot rated
- C;CnormalNot rated
- T;TNo summary available.Not rated
rs9465871CDKAL1Typical
- C;C2.2x risk type-2 diabetesBad
- C;T1.2x risk type-2 diabetesBad
- T;TnormalNot rated
rs9494266C6orf217Typical
- G;GNo summary available.Not rated
rs9919713SCARB1Typical
- A;Acommon in complete genomicsGood
rs9930506FTOTypical
- A;AnormalNot rated
- A;GNo summary available.Not rated
- G;GNo summary available.Not rated
rs10192566LPIN1Typical
- C;Cif diabetic, poorer response to rosiglitazoneNot rated
- C;Gif diabetic, better response to rosiglitazoneNot rated
- G;Gif diabetic, better response to rosiglitazoneNot rated
rs11868035SREBF1Typical
- A;A1.19x increased risk for T2DBad
- A;G1.19x increased risk for T2DBad
- G;GnormalNot rated
rs11964281ESR1Typical
- C;CNo summary available.Good
rs12304921SLC11A2Typical
- A;AnormalGood
- A;G2.5x risk type 2 diabetesBad
- G;G1.9x risk type 2 diabetesBad
rs17036314PPARGTypical
- C;Crisk of progressing from IGT to T2D; reduced by exerciseNot rated
- C;Grisk of progressing from IGT to T2D; reduced by exerciseBad
- G;GnormalNot rated
rs200185429SLC30A8Important
- C;Ccommon/normalGood
- C;TLower type-2 diabetes riskGood
rs114285050GPR151Worth knowing
- A;GSlightly lower odds of obesity as well as coronary artery diseaseGood
- G;Gcommon/normalGood

Genes

FTO4
PPARG4
CDKAL13
KCNQ13
PTPRS3
SLC30A83
SREBF13
TCF7L23
TUB3
HHEX2
HNF1B2
IGF2BP22

Genosets

Gs197Increased type-2 diabetes riskWorth knowing

Genosets combine several genotypes. Twofold checks them in your report.

Other SNPs

No notable genotype or detailed notes

Show 44 SNPs

Source and license

Adapted from Type-2 diabetes on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.