rs1111875

A SNP on chromosome 10. Its most notable genotype is T;T: 1x normal risk of T2D

Gene
None listed
Location
Chr 1092,703,125 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
44%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableNot rated1x normal risk of T2DTypical · 0.021% of people
  2. C;TNot rated1.3x risk of type-2 diabetesTypical · 0.041% of people
  3. C;CNot rated2.4x risk of type-2 diabetesTypical · 0.038% of people
  4. A;ANot ratedNo summary available.Typical · 0.00% of people

SNPedia records rs1111875 on the minus strand: (A;A), (A;G), (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 21% C;T 41% C;C 38% A;A 0%
  • European ancestry (Utah)T;T 17% C;T 50% C;C 34% A;A 0%
  • Han Chinese (Beijing)T;T 44% C;T 45% C;C 12% A;A 0%
  • Japanese (Tokyo)T;T 49% C;T 36% C;C 15% A;A 0%
  • Yoruba (Nigeria)T;T 1% C;T 21% C;C 77% A;A 0%
  • African ancestry (Southwest US)T;T 7% C;T 32% C;C 61% A;A 0%
  • Chinese (Denver)T;T 48% C;T 42% C;C 10% A;A 0%
  • Gujarati IndianT;T 33% C;T 53% C;C 15% A;A 0%
  • Luhya (Kenya)T;T <1% C;T 35% C;C 64% A;A 0%
  • Mexican ancestry (Los Angeles)T;T 7% C;T 59% C;C 35% A;A 0%
  • Maasai (Kenya)T;T 5% C;T 38% C;C 57% A;A 0%
  • TuscanT;T 20% C;T 41% C;C 39% A;A 0%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 200 words

rs1111875 is a SNP of the HHEX homeobox gene. In several studies, it has been associated with risk for type-2 diabetes (T2D). In a study of 500 unrelated Caucasian T2D patients, the rs1111875(G) allele was overrepresented; the odds ratio was 1.68 (CI: 1.19-2.35, p=0.003). In this population, the population attributable risk for this allele was estimated to be 36%. In a study of ~400 Japanese, rs1111875(G) was also associated with type-2 diabetes (odds ratio 1.42, CI: 1.13-1.78, p=0.0024). Heterozygous and homozygous carriers of the risk allele had odds ratios of 1.31 (CI: 0.97-1.77, p=0.0810) and 2.40 (CI: 1.34-4.32, p=0.0028) relative to non-carriers. And in a third study, 1,630 Japanese patients were also found to have this SNP significantly overrepresented (p=0.0064). rs1111875 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.27 (CI: 1.14-1.40, p = 1.4 x 10e-5) 1,638 type 2 diabetes patients and 1,858 controls *rs1111875 non-significant rs7923837 and rs1111875 were significantly associated with decreased insulin secretion and lower insulinogenic index. Reduced insulin clearance was also observed in heterozygous carriers of rs1111875

Source and license

Adapted from rs1111875 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.