rs9402571

A SNP in the SGK1 gene on chromosome 6. Its most notable genotype is G;G: 0.85x decreased risk for type-2 diabetes

Gene
SGK1
Location
Chr 6134,167,822 (GRCh38)
Highest magnitude
1.8Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
26%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableGood0.85x decreased risk for type-2 diabetesMinor · 1.88% of people
  2. G;TGoodslightly decreased risk for type-2 diabetesMinor · 1.436% of people
  3. T;TNot ratednormalTypical · 0.056% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 8% G;T 36% T;T 56%
  • European ancestry (Utah)G;G 4% G;T 26% T;T 70%
  • Han Chinese (Beijing)G;G 15% G;T 50% T;T 35%
  • Japanese (Tokyo)G;G 14% G;T 41% T;T 44%
  • Yoruba (Nigeria)G;G 8% G;T 35% T;T 57%
  • African ancestry (Southwest US)G;G 11% G;T 35% T;T 54%
  • Chinese (Denver)G;G 15% G;T 51% T;T 34%
  • Gujarati IndianG;G 2% G;T 30% T;T 68%
  • Luhya (Kenya)G;G 7% G;T 40% T;T 53%
  • Mexican ancestry (Los Angeles)G;G 3% G;T 24% T;T 72%
  • Maasai (Kenya)G;G 8% G;T 30% T;T 62%
  • TuscanG;G 5% G;T 31% T;T 64%

Conditions, medicines and genes

Other SGK1 SNPs

All SGK1 SNPs

Notes

From SNPedia

Notes

rs9402571 is a SNP in the serum/glucocorticoid regulated kinase 1 SGK1 gene. Three independent European populations were analyzed, with follow up in 3798 non-diabetic and 659 diabetic (type 2) individuals, for associations between SGK1 SNPs and insulin secretion. In lean non-diabetic individuals, rs9402571(G) minor allele carriers had higher (better) insulin response and lower prevalence of type-2 diabetes, with an odds ratio of 0.85 (CI: 0.7-1.0, p = .065, dominant model).

Source and license

Adapted from rs9402571 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.