rs1978237

A SNP in the PTPRS gene on chromosome 19. Its most notable genotype is C;C: >1.59x risk of Type 2 diabetes

Gene: PTPRS
Location: Chr 195,209,630 (GRCh38)
Highest magnitude: 1.6Minor
Tested on: 23andMe
Minor allele frequency: 26%

Genotypes

As shown in 23andMe and AncestryDNA files.

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

AverageC;C 7% C;G 37% G;G 55%
European ancestry (Utah)C;C 5% C;G 51% G;G 45%
Han Chinese (Beijing)C;C 11% C;G 27% G;G 62%
Japanese (Tokyo)C;C 9% C;G 50% G;G 41%
Yoruba (Nigeria)C;C 5% C;G 22% G;G 73%

Conditions, medicines and genes

Type-2 diabetesCondition

Other PTPRS SNPs

All PTPRS SNPs

Notes

From SNPedia

Show notes, about 130 words

rs1143699, rs4807015, and rs1978237 confer an increased risk of developing type-2 diabetes. "SNP rs1143699 was associated with male T2D patients when compared with NGT controls (odds ratio; OR = 1.57; P = 0.029). SNP rs4807015 showed association with T2D patients when compared with NGT controls (OR = 1.32; P = 0.025). Finally, SNP rs1978237 was associated with T2D patients when compared with NGT controls (OR = 1.59; P = 0.002). Logistic regression analysis demonstrated that for SNP rs1143699 in men, C/C homozygosity conveys an increased risk of T2D (OR = 2.19; P = 0.035), while SNP rs4807015 was associated with an increased risk of T2D in both men and women (OR = 1.74; P = 0.029). SNP rs1978237 also demonstrated a risk of T2D in men and women (OR = 1.59; P = 0.026)." (Abstract)

Source and license

Adapted from rs1978237 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.