rs1143699

A SNP in the PTPRS gene on chromosome 19. Its most notable genotype is G;G: In men, 2.19x risk of type 2 diabetes

Gene
PTPRS
Location
Chr 195,210,751 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
9%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBadIn men, 2.19x risk of type 2 diabetesWorth knowing · 2.077% of people

SNPedia records rs1143699 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageG;G 77%
  • European ancestry (Utah)G;G 88%
  • Han Chinese (Beijing)G;G 100%
  • Japanese (Tokyo)G;G 100%
  • Yoruba (Nigeria)G;G 59%
  • African ancestry (Southwest US)G;G 60%
  • Gujarati IndianG;G 88%
  • Luhya (Kenya)G;G 56%
  • Mexican ancestry (Los Angeles)G;G 95%
  • Maasai (Kenya)G;G 54%
  • TuscanG;G 75%

Conditions, medicines and genes

Other PTPRS SNPs

All PTPRS SNPs

Notes

From SNPedia

Notes

rs1143699, rs4807015, and rs1978237 confer an increased risk of developing type-2 diabetes "Logistic regression analysis demonstrated that for SNP rs1143699 in men, C/C homozygosity conveys an increased risk of T2D (OR = 2.19; P = 0.035)," (Abstract)

Source and license

Adapted from rs1143699 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.