rs4807015

A SNP in the PTPRS gene on chromosome 19. Its most notable genotype is C;C: >1.74x risk of type 2 diabetes

Gene
PTPRS
Location
Chr 195,231,124 (GRCh38)
Highest magnitude
1.8Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
41%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad>1.74x risk of type 2 diabetesMinor · 1.821% of people
  2. C;TBad1.74x risk of type 2 diabetesMinor · 1.734% of people
  3. T;TNot ratedNo increased risk of Type 2 diabetesMinor · 1.045% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 21% C;T 34% T;T 45%
  • European ancestry (Utah)C;C 18% C;T 51% T;T 31%
  • Han Chinese (Beijing)C;C 47% C;T 45% T;T 7%
  • Japanese (Tokyo)C;C 47% C;T 48% T;T 5%
  • Yoruba (Nigeria)C;C 0% C;T 4% T;T 96%
  • African ancestry (Southwest US)C;C 0% C;T 23% T;T 77%
  • Chinese (Denver)C;C 52% C;T 42% T;T 6%
  • Gujarati IndianC;C 27% C;T 46% T;T 28%
  • Luhya (Kenya)C;C 0% C;T 5% T;T 96%
  • Mexican ancestry (Los Angeles)C;C 14% C;T 38% T;T 48%
  • Maasai (Kenya)C;C 3% C;T 24% T;T 74%
  • TuscanC;C 19% C;T 54% T;T 28%

Conditions, medicines and genes

Other PTPRS SNPs

All PTPRS SNPs

Notes

From SNPedia

Notes

rs1143699, rs4807015, and rs1978237 confer an increased risk of developing type-2 diabetes. " SNP rs4807015 was associated with an increased risk of T2D in both men and women (OR = 1.74; P = 0.029)" (Abstract) Risk of ovarian cancer and inherited variants in relapse-associated genes.

Source and license

Adapted from rs4807015 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.