rs358806

A SNP on chromosome 3. Its most notable genotype is C;C: 1.78x increased risk of developing Type-2 diabetes

Gene
None listed
Location
Chr 355,279,372 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
19%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodNormal risk of developing Type-2 diabetesMinor · 1.03% of people
  2. A;CBad0.86x increased risk of developing Type-2 diabetesMinor · 1.524% of people
  3. C;CMost notableBad1.78x increased risk of developing Type-2 diabetesWorth knowing · 2.073% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 3% A;C 24% C;C 73%
  • European ancestry (Utah)A;A 5% A;C 35% C;C 59%
  • Han Chinese (Beijing)A;A 2% A;C 28% C;C 70%
  • Japanese (Tokyo)A;A 8% A;C 43% C;C 49%
  • Yoruba (Nigeria)A;A 0% A;C 17% C;C 83%
  • African ancestry (Southwest US)A;A 2% A;C 23% C;C 75%
  • Chinese (Denver)A;A <1% A;C 28% C;C 72%
  • Gujarati IndianA;A 1% A;C 18% C;C 81%
  • Luhya (Kenya)A;A <1% A;C 12% C;C 87%
  • Mexican ancestry (Los Angeles)A;A 2% A;C 25% C;C 74%
  • Maasai (Kenya)A;A 0% A;C 10% C;C 90%
  • TuscanA;A 6% A;C 27% C;C 68%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs358806 has been reported in a large study to be associated with type-2 diabetes. The risk allele is (C); the odds ratio associated with heterozygotes is 0.86 (CI 0.75-0.97), and for homozygotes, 1.78 (CI 1.34-2.36).

Source and license

Adapted from rs358806 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.