rs17782313

A SNP in the MC4R gene on chromosome 18. Its most notable genotype is C;C: adults likely to be 0.44 BMI units higher

Gene
MC4R
Location
Chr 1860,183,864 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
22%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadadults likely to be 0.44 BMI units higherWorth knowing · 2.56% of people
  2. C;TBadadults likely to be 0.22 BMI units higherWorth knowing · 2.038% of people
  3. T;TGoodnormalTypical · 0.057% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 6% C;T 38% T;T 57%
  • European ancestry (Utah)C;C 4% C;T 46% T;T 50%
  • Han Chinese (Beijing)C;C 3% C;T 33% T;T 64%
  • Japanese (Tokyo)C;C 7% C;T 40% T;T 53%
  • Yoruba (Nigeria)C;C 9% C;T 42% T;T 50%
  • African ancestry (Southwest US)C;C 7% C;T 40% T;T 53%
  • Chinese (Denver)C;C 3% C;T 28% T;T 69%
  • Gujarati IndianC;C 8% C;T 43% T;T 50%
  • Luhya (Kenya)C;C 6% C;T 45% T;T 50%
  • Mexican ancestry (Los Angeles)C;C 4% C;T 23% T;T 74%
  • Maasai (Kenya)C;C 4% C;T 34% T;T 62%
  • TuscanC;C 9% C;T 42% T;T 49%

Conditions, medicines and genes

Other MC4R SNPs

All MC4R SNPs

Notes

From SNPedia

Show notes, about 140 words

A study of 60,000 adults indicates that rs17782313(C) alleles are associated with higher body mass index (BMI), with even greater effect in children. The average increase in BMI is 0.22 BMI units (p = 2.8 x 10 -15 ). Note that rs10871777 is considered an equivalent SNP in Caucasian and Asian populations. The rs17782313(C) allele is equivalent to the rs10871777(G) allele.blog.23andme.com The rs17782313(C) allele is significantly associated with higher intakes of total energy and dietary fat. In addition, the SNP was related to greater long-term weight change and increased risk of diabetes in women. rs17782313(C) more snacking, however rs1421085(C) did not influence eating behavior obesity and type-2 diabetes *rs1121980 *rs7498665 *rs4752856 *rs17782313 *rs2815752 *rs10938397

Source and license

Adapted from rs17782313 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.