rs52820871

A SNP in the MC4R gene on chromosome 18. Its most notable genotype is G;T: lower BMI; decreased obesity risk

Gene
MC4R
Location
Chr 1860,371,599 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;TMost notableGoodlower BMI; decreased obesity riskWorth knowing · 2.0

On SNPedia: (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other MC4R SNPs

All MC4R SNPs

Notes

From SNPedia

Notes

Melanocortin-4 receptor gene variant I103 is negatively associated with obesity. A novel melanocortin-4 receptor mutation MC4R-P272L associated with severe obesity has increased propensity to be ubiquitinated in the ER in the face of correct folding. A novel melanocortin-4 receptor mutation MC4R-P272L associated with severe obesity has increased propensity to be ubiquitinated in the ER in the face of correct folding.

Source and license

Adapted from rs52820871 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.