rs13447324
A SNP in the MC4R gene on chromosome 18. Its most notable genotype is G;T: Obesity related mutation
- Gene
- MC4R
- Location
- Chr 1860,372,245 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;TMost notableBadObesity related mutation
- G;GGoodcommon in clinvar
SNPedia records rs13447324 on the minus strand: (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other MC4R SNPs
- rs17782313C;Cadults likely to be 0.44 BMI units higherWorth knowing
- rs2229616T;Tlower risk of metabolic syndromeWorth knowing
- rs10871777G;Gadults likely to be 0.44 BMI units higherWorth knowing
- rs52820871G;Tlower BMI; decreased obesity riskWorth knowing
- rs12970134A;Aadult waist 1.8cm larger on averageTypical
Notes
From SNPedia
Notes
aka c.105C>A (p.Tyr35Ter) This nonsense mutation in the MC4R gene has been reported by multiple ClinVar submitters as pathogenic for obesity. It is also discussed in OMIM 1555541.0003, apparently as a dominantly inherited mutation.
G;T
See text and links via main rs-page
Source and license
Adapted from rs13447324 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.