rs10871777

A SNP in the MC4R gene on chromosome 18. Its most notable genotype is G;G: adults likely to be 0.44 BMI units higher

Gene
MC4R
Location
Chr 1860,184,530 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
23%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodnormalTypical · 0.056% of people
  2. A;GBadadults likely to be 0.22 BMI units higherWorth knowing · 2.038% of people
  3. G;GMost notableBadadults likely to be 0.44 BMI units higherWorth knowing · 2.16% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 56% A;G 38% G;G 6%
  • European ancestry (Utah)A;A 50% A;G 47% G;G 4%
  • Han Chinese (Beijing)A;A 64% A;G 33% G;G 3%
  • Japanese (Tokyo)A;A 53% A;G 40% G;G 7%
  • Yoruba (Nigeria)A;A 48% A;G 44% G;G 9%
  • African ancestry (Southwest US)A;A 53% A;G 40% G;G 7%
  • Chinese (Denver)A;A 69% A;G 28% G;G 3%
  • Gujarati IndianA;A 49% A;G 43% G;G 8%
  • Luhya (Kenya)A;A 47% A;G 45% G;G 8%
  • Mexican ancestry (Los Angeles)A;A 71% A;G 24% G;G 5%
  • Maasai (Kenya)A;A 62% A;G 34% G;G 4%
  • TuscanA;A 46% A;G 45% G;G 9%

Other MC4R SNPs

All MC4R SNPs

Notes

From SNPedia

Notes

See rs17782313 for details. Measures of Obesity

Source and license

Adapted from rs10871777 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.