rs7756992

A SNP in the CDKAL1 gene on chromosome 6. Its most notable genotype is A;A: normal

Gene
CDKAL1
Location
Chr 620,679,478 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
41%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodnormalTypical · 0.034% of people
  2. A;GBad1.3x increased risk for type-2 diabetesTypical · 0.044% of people
  3. G;GBad1.3x increased risk for type-2 diabetesTypical · 0.022% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 34% A;G 44% G;G 22%
  • European ancestry (Utah)A;A 53% A;G 38% G;G 9%
  • Han Chinese (Beijing)A;A 25% A;G 50% G;G 26%
  • Japanese (Tokyo)A;A 30% A;G 47% G;G 22%
  • Yoruba (Nigeria)A;A 20% A;G 44% G;G 36%
  • African ancestry (Southwest US)A;A 18% A;G 60% G;G 23%
  • Chinese (Denver)A;A 28% A;G 42% G;G 29%
  • Gujarati IndianA;A 57% A;G 38% G;G 5%
  • Luhya (Kenya)A;A 20% A;G 44% G;G 36%
  • Mexican ancestry (Los Angeles)A;A 40% A;G 52% G;G 9%
  • Maasai (Kenya)A;A 21% A;G 41% G;G 39%
  • TuscanA;A 59% A;G 34% G;G 7%

Conditions, medicines and genes

Other CDKAL1 SNPs

All CDKAL1 SNPs

Notes

From SNPedia

Show notes, about 180 words

Polycystic Kidney disease rs7756992 significantly p = 0.0363 associated with type-2 diabetes in 1,630 Japanese subjects and in 1,064 controls rs7756992 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.27 (CI: 1.15-1.40, p = 9.8 x 10e-7) 1,638 type 2 diabetes patients and 1,858 controls *rs7756992 non-significant T2D and normal glucose tolerant (NGT) individuals. (3,295 T2D and 3,595 NGT), strong associations with T2D were found for *CDKAL1 (OR(rs7756992) = 1.30[1.19-1.42], P = 2.3x10(-9)) *CDKN2A/2B (OR(rs10811661) = 0.74[0.66-0.82], P = 3.5x10(-8)) *IGFBP2 (OR(rs1470579) = 1.17[1.07-1.27], P = 0.0003) SNPs. T2D risk increased strongly when risk alleles, including the previously discovered T2D-associated TCF7L2 rs7903146 SNP, were combined (8.68-fold for the 14% of French individuals carrying 18 to 30 risk alleles with an allelic OR of 1.24) This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).

Source and license

Adapted from rs7756992 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.