rs6908425

A SNP in the CDKAL1 gene on chromosome 6. Its most notable genotype is C;C: 1.95x increased risk of developing Crohn's disease

Gene
CDKAL1
Location
Chr 620,728,500 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
22%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad1.95x increased risk of developing Crohn's diseaseWorth knowing · 2.061% of people
  2. C;TBad1.63x increased risk of developing Crohn's diseaseMinor · 1.534% of people
  3. T;TGoodNormal risk of developing Crohn's diseaseMinor · 1.05% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 61% C;T 34% T;T 5%
  • European ancestry (Utah)C;C 66% C;T 34% T;T <1%
  • Han Chinese (Beijing)C;C 65% C;T 33% T;T 2%
  • Japanese (Tokyo)C;C 60% C;T 33% T;T 7%
  • Yoruba (Nigeria)C;C 61% C;T 33% T;T 6%
  • African ancestry (Southwest US)C;C 63% C;T 32% T;T 5%
  • Chinese (Denver)C;C 67% C;T 31% T;T 2%
  • Gujarati IndianC;C 49% C;T 45% T;T 6%
  • Luhya (Kenya)C;C 47% C;T 46% T;T 6%
  • Mexican ancestry (Los Angeles)C;C 60% C;T 33% T;T 7%
  • Maasai (Kenya)C;C 76% C;T 22% T;T 1%
  • TuscanC;C 60% C;T 34% T;T 6%

Conditions, medicines and genes

Other CDKAL1 SNPs

All CDKAL1 SNPs

Notes

From SNPedia

Notes

rs6908425 has been reported in a large study to be associated with Crohn's disease. The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.63 (CI 1.38-2.25), and for homozygotes, 1.95 (CI 1.43-2.67).

Source and license

Adapted from rs6908425 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.