rs7754840
A SNP in the CDKAL1 gene on chromosome 6. Its most notable genotype is C;C: 1.3x increased risk for type-2 diabetes
- Gene
- CDKAL1
- Location
- Chr 620,661,019 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 41%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableBad1.3x increased risk for type-2 diabetes
- C;GBad1.3x increased risk for type-2 diabetes
- G;GGoodnormal
On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 20% C;G 45% G;G 34%
- European ancestry (Utah)C;C 10% C;G 48% G;G 43%
- Han Chinese (Beijing)C;C 15% C;G 52% G;G 34%
- Japanese (Tokyo)C;C 14% C;G 50% G;G 35%
- Yoruba (Nigeria)C;C 47% C;G 40% G;G 14%
- African ancestry (Southwest US)C;C 30% C;G 60% G;G 11%
- Chinese (Denver)C;C 18% C;G 41% G;G 40%
- Gujarati IndianC;C 6% C;G 33% G;G 61%
- Luhya (Kenya)C;C 36% C;G 45% G;G 19%
- Mexican ancestry (Los Angeles)C;C 10% C;G 43% G;G 47%
- Maasai (Kenya)C;C 29% C;G 51% G;G 21%
- TuscanC;C 10% C;G 37% G;G 53%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 160 words
The accuracy of claims about this snp are called into question by table 1 of discusses the process of including this snp into Coriell and raises some doubt about the value of its inclusion. rs7754840 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.28 (CI: 1.17-1.41, p = 4.5 x 10e-7) type-2 diabetes Carriers of the (C;G) and (C;C) genotypes of rs7754840 had 11% and 24% lower first-phase insulin release in an IVGTT compared to that in carriers of the (G;G) genotype (P=0.002). The C allele was also associated with higher glucose area under the curve in an OGTT (P=0.016). rs7754840 type-2 diabetes Ashkenazi Jewish population shows an even stronger effect for rs7754840 than the general Caucasian population, based on 1,131 cases versus 1,147 controls. This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).
Source and license
Adapted from rs7754840 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.