Cancer

33 SNPs linked to Cancer across 24 genes, 21 with a genotype of magnitude 2 or higher.

Type: Condition
SNPs: 33
Notable: 21Magnitude 2 or higher
Well documented: 30
Genes: 24

Linked SNPs

Every genotype, as shown in 23andMe and AncestryDNA files.

rs768966657CDKN2AVery important
- -;-common/normalGood
- -;GACFor those w/ cancer, a slightly worse prognosis; also, slightly increased melanoma riskBad
rs1800562LOC108783645Very important
- A;ATwo copies of C282Y, likely affected by hemochromatosis which may be serious if male or post-menopausal.Bad
- A;GOne copy of C282Y, carrier of hemochromatosis, likely unaffected unless also H63D carrier.Bad
- G;GNot a C282Y hemochromatosis carrier.Good
rs671ALDH2Very important
- A;AAsian Flusher; increased risk of esophageal cancer; East Asian ancestry; Disulfiram not effective for alcoholism.Bad
- A;GAsian Flush; worse hangovers; increased risk of esophageal cancer; East Asian ancestry; Disulfiram probably not effective for alcoholism.Bad
- G;GAlcohol Flush: Normal, doesn't flush. Normal hangovers. Normal risk of Alcoholism. Normal risk of Esophageal Cancer. Disulfiram is effective for alcoholism.Good
rs7903146TCF7L2Important
- C;CNormal (lower) risk of Type 2 Diabetes and Gestational Diabetes.Good
- C;T1.4x increased risk for diabetes (and perhaps colon cancer).Bad
- T;T2x increased risk for Type-2 diabetesBad
rs6983267CASC8Important
- G;G1.6x increased risk for prostate cancer; also other cancersBad
- G;T1.3x risk of prostate cancer; aspirin reduces risk of colorectal cancerBad
- T;Tnormal risk for cancers; aspirin reduces risk for colorectal cancerGood
rs1042522TP53Important
- G;GLive 3 years longer. Chemotherapy is more effective.Good
- C;GSlightly increased lifespan?Good
- C;CCommon variant. Slightly shorter lifespan.Bad
rs1801133MTHFRWorth knowing
- G;GCommon genotype: normal homocysteine levelsGood
- A;G1 copy of C677T allele of MTHFR = 65% efficiency in processing folic acidBad
- A;Ahomozygous for C677T of MTHFR = 10-20% efficiency in processing folic acid = high homocysteine, low B12 and folate levelsBad
rs1801131MTHFRWorth knowing
- T;Tmost common genotypeGood
- G;TPossibly impaired folate metabolismBad
- G;GNumber of risks. Complex.Bad
rs1695GSTP1Worth knowing
- A;Anormal asthma risk in certain populationsGood
- A;G?Not rated
- G;G3.5x asthma risk in certain populationsBad
rs1050631SLC39A6Worth knowing
- G;GMean Survival Time of 32 months for esophageal squamous-cell carcinomaGood
- A;GMean Survival Time of 25 months for esophageal squamous-cell carcinomaBad
- A;AMean Survival Time of 17 months for esophageal squamous-cell carcinomaBad
rs2273535AURKAWorth knowing
- A;AcommonNot rated
- A;Tslightly higher (~1.5x or less) risk for certain cancersBad
- T;Tslightly higher (~1.5x or less) risk for certain cancersBad
rs2279744MDM2Worth knowing
- G;GGenerally more cancer proneBad
- G;TSlightly more cancer prone; commonBad
- T;TnormalGood
rs25487XRCC1Worth knowing
- T;T0.7x lower risk for skin cancerGood
- C;T2x higher risk for skin cancer; possibly other cancersBad
- C;C2x higher risk for skin cancer; possibly other cancersBad
rs763110FASLGWorth knowing
- C;CnormalBad
- C;T~0.80x reduced cancer riskGood
- T;T~0.80x reduced cancer riskGood
rs1041981LOC100287329Worth knowing
- A;AHigher myocardial infarction riskBad
- C;CnormalNot rated
rs1169300HNF1AWorth knowing
- A;A~2x increased lung cancer riskBad
- A;G~1.5x increased lung cancer riskBad
- G;GnormalNot rated
rs1800795IL6Worth knowing
- C;Cless IL6; certain risks, see detailsBad
- C;Gcomplex; see detailsNot rated
- G;Gmore IL6; certain risks, see detailsBad
rs1801394MTRRWorth knowing
- A;Acommon/normalGood
- A;GnormalNot rated
- G;G1.4x higher risk for meningiomasBad
rs2464196HNF1AWorth knowing
- G;GnormalGood
- A;G~1.5x increased lung cancer riskBad
- A;A~2x increased lung cancer riskBad
rs9642880CASC11Worth knowing
- G;GSlightly lower risk of Bladder Cancer.Good
- G;T1.2x increased bladder cancer riskBad
- T;T1.5x increased bladder cancer riskBad
rs11614913MIR196A2Worth knowing
- C;CSomewhat increased risk of various types of cancerBad
- C;TnormalNot rated
- T;Tdecreased risk for colorectal cancer and lung cancerGood
rs401681CLPTM1LMinor
- C;C~1.2x increased risk for several types of cancerBad
- C;T~1.2x increased risk for several types of cancerBad
- T;TnormalNot rated
rs1892534Minor
- T;TLower C-Reactive Protein levels. 1.2x increased risk overall for cancers.Bad
- C;TNormal C-Reactive Protein levels. Very slight (x1.05) increase in overall risk for cancers.Not rated
- C;CSlightly higher C-Reactive Protein levels. Possibly slightly lower cancer risk.Good
rs1799782XRCC1Minor
- G;Glower risk for skin cancerGood
- A;G1.3x increased risk for oral cancer among AsiansNot rated
- A;A1.4x increased risk for oral cancer among AsiansNot rated
rs3738579RNASELMinor
- G;G0.6x decreased risk for cervical cancer, but 1.4x increased risk for HNSCC and 1.8x increased risk for breast cancer (reported in 2008)Bad
- A;G0.5x decreased risk for cervical cancer, HNSCC, and breast cancer (reported in 2008)Good
- A;A1.5x - 2x increased risk for cervical cancer, HNSCC, and breast cancer (reported in 2008)Bad
rs2228000XPCMinor
- G;GnormalGood
- A;GnormalNot rated
- A;Astatistically significant, but slight, increase in bladder cancer riskBad
rs1047972AURKATypical
- C;Ccommon/normalGood
rs1801270CDKN1ATypical
- A;Aincreased risk for lung cancerBad
- A;Cincreased risk for lung cancerBad
- C;Cnormal riskGood
rs2228001XPCTypical
- T;TNo summary available.Not rated
- G;TnormalNot rated
- G;GnormalGood
rs2736098TERTTypical
- T;Tslightly increased risk for several types of cancersBad
- C;Tslightly increased risk for several types of cancersBad
- C;CnormalGood

Genes

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Other SNPs

No notable genotype or detailed notes

Show 3 SNPs

Source and license

Adapted from Cancer on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.