rs763110

A SNP in the FASLG gene on chromosome 1. Its most notable genotype is C;T: ~0.80x reduced cancer risk

Gene
FASLG
Location
Chr 1172,658,358 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
43%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CBadnormalTypical · 0.028% of people
  2. C;TMost notableGood~0.80x reduced cancer riskWorth knowing · 2.041% of people
  3. T;TGood~0.80x reduced cancer riskWorth knowing · 2.032% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 28% C;T 41% T;T 32%
  • European ancestry (Utah)C;C 36% C;T 49% T;T 15%
  • Han Chinese (Beijing)C;C 57% C;T 40% T;T 3%
  • Japanese (Tokyo)C;C 57% C;T 37% T;T 6%
  • Yoruba (Nigeria)C;C <1% C;T 17% T;T 82%
  • African ancestry (Southwest US)C;C 5% C;T 46% T;T 49%
  • Chinese (Denver)C;C 51% C;T 43% T;T 6%
  • Gujarati IndianC;C 16% C;T 46% T;T 38%
  • Luhya (Kenya)C;C 2% C;T 18% T;T 80%
  • Mexican ancestry (Los Angeles)C;C 41% C;T 55% T;T 4%
  • Maasai (Kenya)C;C 5% C;T 44% T;T 51%
  • TuscanC;C 35% C;T 51% T;T 14%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs763110, also known as -844C>T, is a SNP in the FAS ligand FASLG gene. A meta-analysis of 19 published studies, including 11,105 cancer cases and 11,372 controls, concluded that the rs763110(C;T) and (T;T) genotypes were associated with a significantly reduced (about 0.80x) cancer risk of all cancer types.

Source and license

Adapted from rs763110 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.