rs1799782

A SNP in the XRCC1 gene on chromosome 19. Its most notable genotype is A;A: 1.4x increased risk for oral cancer among Asians

Gene
XRCC1
Location
Chr 1943,553,422 (GRCh38)
Highest magnitude
1.4Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
13%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodlower risk for skin cancerTypical · 0.069% of people
  2. A;GNot rated1.3x increased risk for oral cancer among AsiansMinor · 1.327% of people
  3. A;AMost notableNot rated1.4x increased risk for oral cancer among AsiansMinor · 1.44% of people

SNPedia records rs1799782 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 69% A;G 27% A;A 4%
  • European ancestry (Utah)G;G 85% A;G 12% A;A 3%
  • Han Chinese (Beijing)G;G 56% A;G 40% A;A 4%
  • Japanese (Tokyo)G;G 51% A;G 42% A;A 7%
  • Yoruba (Nigeria)G;G 85% A;G 13% A;A 2%

Conditions, medicines and genes

Other XRCC1 SNPs

All XRCC1 SNPs

Notes

From SNPedia

Show notes, about 180 words

rs1799782, a SNP also known as Arg194Trp located in the DNA-repair gene XRCC1, is associated with a reduced risk for certain types of cancer. The (T) allele encodes the Trp amino acid. A study of ~200 Korean cases of skin cancer indicated that the rs1799782(T;T) genotype was inversely associated with squamous cell cancer risk (adjusted odds ratio 0.06, CI: 0.006-0.63). A meta-analysis of 8 case-control studies concluded that significant association was found between the rs1799782 polymorphism and oral cancer risk among Asians, showing an odds ratio of 1.347 (CI: 1.0 - 1.81) for allele comparison, 1.378 (CI: 1.070 - 1.775) for (T;T) homozygotes vs (C;C) homozygotes, and 1.420 (CI: 1.041 - 1.936) for comparison under a dominant model. 18067C>T possibly related to non-Hodgkin lymphoma rs2040639-AG, contribute to oral cancer risk. pseudo-haplotype with AG-CC genotypes in *2.45x risk rs2040639-rs861539 *5.03x risk rs2040639-rs861539-rs2075685 *10.10x risk rs2040639-rs861539-rs2075685-rs1799782 A meta-analysis concludes that this SNP is not associated with risk of gastric cancer.

Source and license

Adapted from rs1799782 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.