Melanoma

27 SNPs linked to Melanoma across 13 genes, 17 with a genotype of magnitude 2 or higher.

Type: Condition
SNPs: 27
Notable: 17Magnitude 2 or higher
Well documented: 18
Genes: 13

Linked SNPs

Every genotype, as shown in 23andMe and AncestryDNA files.

rs587776650NBNVery important
- -;-Nijmegen breakage syndromeBad
- -;TTTGThigher risk for several cancers; carrier for Nijmegen breakage syndrome alleleBad
- TTTGT;TTTGTcommon/normalGood
rs768966657CDKN2AVery important
- -;-common/normalGood
- -;GACFor those w/ cancer, a slightly worse prognosis; also, slightly increased melanoma riskBad
rs746834149CDKN2AVery important
- C;Ccommon/normalGood
- C;TMalignant melanoma predisposing mutationBad
rs777948908CDKN2AVery important
- C;Ccommon/normalGood
- C;GMalignant melanoma predisposing mutationBad
rs910873PIGUVery important
- A;A3x increased risk of melanomaBad
- A;G1.7x increased risk of melanoma; increased risk of squamous cell carcinomaBad
- G;GnormalGood
rs258322CDK10Important
- A;A2x increased risk of MelanomaBad
rs1393350TYRImportant
- A;ANo summary available.Not rated
- A;GNo summary available.Not rated
- G;Gcommon on affy axiom dataGood
rs1805008MC1RImportant
- C;Ccommon in clinvarGood
- C;TRed hair carrier, higher risk of melanomaBad
- T;T~7-10x higher likelihood of red hair; higher risk of melanomaBad
rs2279744MDM2Worth knowing
- G;GGenerally more cancer proneBad
- G;TSlightly more cancer prone; commonBad
- T;TnormalGood
rs13181ERCC2Worth knowing
- G;G>1.12x increased risk for cutaneous melanoma; possible increase in ovarian cancer riskBad
- G;T1.12x increased risk for cutaneous melanomaBad
- T;TNormal risk for cutaneous melanomaGood
rs1799944BRCA2Worth knowing
- A;Acommon in complete genomicsGood
- G;GNo summary available.Bad
rs401681CLPTM1LMinor
- C;C~1.2x increased risk for several types of cancerBad
- C;T~1.2x increased risk for several types of cancerBad
- T;TnormalNot rated
rs4785763AFG3L1Minor
- A;A2x higher risk for melanomaBad
- A;C1.5x higher risk for melanomaBad
- C;CcommonGood
rs4845618IL6RMinor
- G;GnormalNot rated
- G;T1.7x increased melanoma riskBad
- T;Tnormal?Not rated
rs1800407OCA2Minor
- T;Tgreen/hazel/brown/black eyes more likelyNot rated
- C;Tgreen/hazel/brown/black eyes more likelyNot rated
- C;Cblue/gray eyes more possibleNot rated
rs4845622IL6RTypical
- A;AnormalNot rated
- A;C1.7x increased melanoma riskNot rated
- C;Cnormal?Not rated
rs6684439IL6RTypical
- C;CnormalNot rated
- C;T1.7x increased melanoma riskBad
- T;Tnormal?Not rated
rs8192284IL6RTypical
- A;Areduced risk of multiple myelomaGood
- A;C1.7x increased melanoma riskBad
- C;C2.5x increased risk of multiple myeloma versus AA genotypeBad
rs1800586CDKN2AVery important
- C;Ccommon in clinvarGood
- A;CPancreatic cancer/Melanoma SyndromeBad
rs104894097CDKN2AVery important
- C;GMalignant melanoma predisposing mutationBad
- C;Ccommon in complete genomicsGood
rs606231175CDKN2AVery important
- -;-common/normalGood
- -;GGCGGCGGGGAGCAGCATGGAGCCMalignant melanoma predisposing mutationBad
rs730881673CDKN2AVery important
- -;-common in clinvarGood
- -;TMalignant melanoma predisposing mutationBad
- -;AAMalignant melanoma predisposing mutationBad
- -;ACMalignant melanoma predisposing mutationBad
- G;Gcommon in clinvarGood
rs751570838CDKN2AVery important
- -;GGCTCCATGCTGCTCCCCGCCGCCMalignant melanoma predisposing mutationBad
- GGCTCCATGCTGCTCCCCGCCGCC;GGCTCCATGCTGCTCCCCGCCGCCcommon/normalGood
rs878853647CDKN2AVery important
- C;GMalignant melanoma predisposing mutationBad
- C;Ccommon in clinvarGood

Genes

Genosets

Gs195Risk factor for malignant melanomaWorth knowing

Genosets combine several genotypes. Twofold checks them in your report.

Other SNPs

No notable genotype or detailed notes

Show 3 SNPs

Source and license

Adapted from Melanoma on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.