rs6684439

A SNP in the IL6R gene on chromosome 1. Its most notable genotype is C;C: normal

Gene
IL6R
Location
Chr 1154,423,363 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
38%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratednormalTypical · 0.041% of people
  2. C;TBad1.7x increased melanoma riskTypical · 0.045% of people
  3. T;TNot ratednormal?Typical · 0.014% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 41% C;T 45% T;T 14%
  • European ancestry (Utah)C;C 43% C;T 44% T;T 12%
  • Han Chinese (Beijing)C;C 34% C;T 51% T;T 15%
  • Japanese (Tokyo)C;C 43% C;T 43% T;T 15%
  • Yoruba (Nigeria)C;C 37% C;T 50% T;T 14%
  • African ancestry (Southwest US)C;C 40% C;T 44% T;T 16%
  • Chinese (Denver)C;C 33% C;T 44% T;T 23%
  • Gujarati IndianC;C 47% C;T 48% T;T 6%
  • Luhya (Kenya)C;C 46% C;T 48% T;T 6%
  • Mexican ancestry (Los Angeles)C;C 29% C;T 40% T;T 31%
  • Maasai (Kenya)C;C 63% C;T 33% T;T 4%
  • TuscanC;C 36% C;T 50% T;T 14%

Conditions, medicines and genes

Other IL6R SNPs

All IL6R SNPs

Notes

From SNPedia

Notes

A study of 219 female melanoma patients and an equal number of controls concluded that 4 linked SNPs within the IL6R gene were associated with increased melanoma risk, but only when heterozygous. [Note that there may have been too few minor allele homozygotes to study, though.] The odds ratio associated with the minor allele of this SNP, rs6684439, was 1.74 (CI: 1.07-2.81). The 4 linked SNPs from identified in this study are: rs6684439, rs4845618, rs4845622, and rs8192284.

Source and license

Adapted from rs6684439 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.