rs2229238
A SNP in the IL6R gene on chromosome 1. Its most notable genotype is C;C: common in complete genomics
- Gene
- IL6R
- Location
- Chr 1154,465,420 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 19%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 67%
- European ancestry (Utah)C;C 62%
- Han Chinese (Beijing)C;C 77%
- Japanese (Tokyo)C;C 66%
- Yoruba (Nigeria)C;C 66%
- African ancestry (Southwest US)C;C 48%
- Chinese (Denver)C;C 73%
- Gujarati IndianC;C 64%
- Luhya (Kenya)C;C 64%
- Mexican ancestry (Los Angeles)C;C 72%
- Maasai (Kenya)C;C 69%
- TuscanC;C 70%
Related
Other IL6R SNPs
- rs4845618G;T1.7x increased melanoma riskMinor
- rs7529229C;C2.5x higher risk of multiple myeloma than AAMinor
- rs4129267T;TAssociated with 73% higher IL-R and CRP levelsMinor
- rs2228145A;Acommon in clinvarTypical
- rs4845622A;AnormalTypical
- rs6684439C;CnormalTypical
- rs8192284A;Areduced risk of multiple myelomaTypical
Notes
From SNPedia
Notes
Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma. Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women. Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults.
Source and license
Adapted from rs2229238 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.