rs8192284

A SNP in the IL6R gene on chromosome 1. Its most notable genotype is A;A: reduced risk of multiple myeloma

Gene
IL6R
Location
Chr 1154,454,494 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodreduced risk of multiple myelomaTypical · 0.054% of people
  2. A;CBad1.7x increased melanoma riskTypical · 0.036% of people
  3. C;CBad2.5x increased risk of multiple myeloma versus AA genotypeTypical · 0.011% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 54% A;C 36% C;C 11%
  • European ancestry (Utah)A;A 43% A;C 43% C;C 14%
  • Han Chinese (Beijing)A;A 37% A;C 48% C;C 15%
  • Japanese (Tokyo)A;A 43% A;C 43% C;C 14%
  • Yoruba (Nigeria)A;A 87% A;C 12% C;C <1%
  • African ancestry (Southwest US)A;A 70% A;C 30% C;C 0%
  • Chinese (Denver)A;A 34% A;C 44% C;C 22%
  • Gujarati IndianA;A 49% A;C 49% C;C 3%
  • Luhya (Kenya)A;A 86% A;C 14% C;C 0%
  • Mexican ancestry (Los Angeles)A;A 28% A;C 41% C;C 31%
  • Maasai (Kenya)A;A 80% A;C 18% C;C 3%
  • TuscanA;A 36% A;C 50% C;C 14%

Conditions, medicines and genes

Other IL6R SNPs

All IL6R SNPs

Notes

From SNPedia

Show notes, about 120 words

A study of 219 female melanoma patients and an equal number of controls concluded that 4 linked SNPs within the IL6R gene were associated with increased melanoma risk, but only when heterozygous. The odds ratio associated with the minor allele of this SNP, rs8192284 (also known as Asp358Ala), was 1.68 (CI: 1.04-2.73). The 4 linked SNPs from identified in this study are: rs6684439, rs4845618, rs4845622, and rs8192284. linked to diabetes by multiple myeloma *rs1801278 [C/T versus C/C genotypes; OR, 4.3; 95% confidence interval (CI), 1.5-12.1] *rs6684439 (T/T versus C/C; OR, 2.9; 95% CI, 1.2-7.0) *rs7529229 (C/C versus T/T; OR, 2.5; 95% CI, 1.1-6.0) *rs8192284 (C/C versus A/A; OR, 2.5, 95% CI, 1.1-6.0)

Source and license

Adapted from rs8192284 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.