Diabetes

31 SNPs linked to Diabetes across 22 genes, 12 with a genotype of magnitude 2 or higher.

Type: Condition
SNPs: 31
Notable: 12Magnitude 2 or higher
Well documented: 27
Genes: 22

Linked SNPs

Every genotype, as shown in 23andMe and AncestryDNA files.

rs1800562LOC108783645Very important
- A;ATwo copies of C282Y, likely affected by hemochromatosis which may be serious if male or post-menopausal.Bad
- A;GOne copy of C282Y, carrier of hemochromatosis, likely unaffected unless also H63D carrier.Bad
- G;GNot a C282Y hemochromatosis carrier.Good
rs76723693G6PDVery important
- G;GG6PD deficiency; Hb1Ac value may need adjusting for diabetes diagnosisBad
- A;GCarrier of G6PD deficiency mutation; variable expressivity; Hb1Ac value may need adjusting for diabetes diagnosisBad
- A;Acommon in clinvarGood
rs1048095ABCC8Very important
- A;GReported to be associated with permanent neonatal diabetes mellitusBad
- A;Acommon in clinvarGood
rs1050828G6PDVery important
- -;CNo summary available.Good
- T;TG6PD deficiency; Hb1Ac value may need adjusting for diabetes diagnosisBad
- C;TG6PD deficiency carrier; Hb1Ac value may need adjusting for diabetes diagnosisBad
- -;CNo summary available.Good
- C;Ccommon in clinvarGood
rs1057910CYP2C9Very important
- A;Anormal; no effect on warfarin metabolismGood
- A;CCYP2C9*3 carrier; average 40% reduction in warfarin metabolismBad
- C;CCYP2C9*3 homozygote; average 80% reduction in warfarin metabolism; reduced metabolism of number of other drugsBad
rs2383206CDKN2BASImportant
- A;AnormalGood
- A;G1.4x increased risk for heart diseaseBad
- G;G1.7x increased risk for heart diseaseBad
rs10757278Worth knowing
- A;A0.78x reduced risk for Coronary Heart Disease. 0.77x reduced risk for Brain Aneurysm and Abdominal Aortic Aneurysm.Good
- A;G1.3x risk for Heart Attack. Normal risk for Abdominal Aortic Aneurysm and Brain Aneurysm.Bad
- G;G1.6x risk for Heart Attack; 1.3x risk for Abdominal Aortic Aneurysm and Brain Aneurysm.Bad
rs5443GNB3Worth knowing
- C;Cnormal, but higher risk for several conditionsGood
- C;Tsome riskBad
- T;Tviagra is more likely to have an effect. increased metabolic disease risk.Bad
rs1233478LOC105375009Worth knowing
- T;TNo summary available.Not rated
rs4585ATMWorth knowing
- G;Gslightly higher (1.35x) odds of good metformin response in type 2 diabeticsGood
- G;Taverage response to metformin in type 2 diabeticsNot rated
- T;Tslightly poorer (0.75x) response to metformin in type 2 diabeticsBad
rs854560PON1Worth knowing
- A;Ahigher risk for heart disease, diabetic retinopathyBad
- A;Thigher risk for heart disease, diabetic retinopathyBad
- T;T0.5x lower risk of ovarian cancerGood
rs4129267IL6RMinor
- C;CNo increased risk of higher IL-R and CRP levelsGood
- T;TAssociated with 73% higher IL-R and CRP levelsBad
rs822387Minor
- C;Cmay have higher adiponectin levelsNot rated
- C;Tmay have higher adiponectin levelsNot rated
rs17300539ADIPOQMinor
- A;Ahigher adiponectin levelsBad
- A;Gif obese, dieting more effectiveNot rated
- G;Gincreased risk of insulin resistanceBad
rs20417PTGS2Typical
- G;GNo summary available.Not rated
- C;GNo summary available.Not rated
- C;Ccommon/normalGood
rs361525TNFTypical
- A;Acomplex; generally higher risk for certain diseasesNot rated
- A;Gcomplex; generally higher risk for certain diseasesNot rated
- G;Gcomplex; generally normal riskGood
rs553668ADRA2ATypical
- G;Gcommon/normalGood
- A;ANo summary available.Not rated
rs1982073TGFB1Typical
- G;Grisk genotype for several disordersNot rated
- A;Grisk genotype for several disordersNot rated
- A;Arisk genotype for several disordersNot rated
rs2144908HNF4ATypical
- A;GNo summary available.Not rated
rs2298298PINK1Typical
- A;Acommon in clinvarGood
rs3131713PINK1Typical
- G;Gcommon in clinvarGood
rs3772534CBLBTypical
- G;GNo summary available.Not rated
- C;Ccommon in complete genomicsGood
rs4293393UMODTypical
- G;G0.76x reduced risk of CKD for C alleleGood
- A;GNo summary available.Good
- A;A1.25x Increased Risk of CKD for T allele in Icelandic studyBad
rs8192284IL6RTypical
- A;Areduced risk of multiple myelomaGood
- A;C1.7x increased melanoma riskBad
- C;C2.5x increased risk of multiple myeloma versus AA genotypeBad
rs10757274CDKN2B-AS1Typical
- A;AnormalNot rated
- A;G~1.2x increased risk for heart diseaseBad
- G;G~1.3x increased risk for heart diseaseBad
rs17366743ADIPOQTypical
- T;TNo summary available.Good
rs71530923WFS1Typical
- C;Ccommon in clinvarGood
rs104894006GCKVery important
- G;Gcommon in clinvarGood
- A;GDiabetes, late-onset noninsulin-dependent (predicted)Bad

Other SNPs

No notable genotype or detailed notes

Show 3 SNPs

Source and license

Adapted from Diabetes on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.

Linked SNPs

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Source and license