rs1050828(C;T)
G6PD deficiency carrier; Hb1Ac value may need adjusting for diabetes diagnosis
- Magnitude
- 3.0Important
- Repute
- Bad
- Frequency
- 7%Average of 8 populations
- On SNPedia
- rs1050828(A;G)Minus strand
- Gene
- G6PD
Frequency
Share of people with C;T in each HapMap population.
- African ancestry (Southwest US)18%
- Yoruba (Nigeria)16%
- Luhya (Kenya)16%
- Mexican ancestry (Los Angeles)2%
- Maasai (Kenya)1%
- European ancestry (Utah)0%
- Han Chinese (Beijing)0%
- Japanese (Tokyo)0%
Other genotypes of rs1050828
Notes
From SNPedia
The rs1050828 A allele is a diagnostic SNP of the type A- G6PD deficiency genotype. While the G allele (rs1050828(G;G)) is associated with 'normal' levels of glucose-6-phosphate dehydrogenase, the A allele is associated with a reduction of G6PD production. Because rs1050828 is located on the X chromosome, only females can be heterozygous for both the A and G allele. Furthermore, due to the process of X chromosome lyonization, the severity of G6PD deficiency will vary across females. G6PD type A- is predominantly found in individuals with African ancestry while the G allele is found in other ethnic groups. The rs1050828 A allele is also associated with malarial resistance.
Related
Source and license
Adapted from rs1050828(A;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.