Asthma

65 SNPs linked to Asthma across 26 genes, 15 with a genotype of magnitude 2 or higher.

Type: Condition
SNPs: 65
Notable: 15Magnitude 2 or higher
Well documented: 35
Genes: 26

Linked SNPs

Every genotype, as shown in 23andMe and AncestryDNA files.

rs1837253TSLPWorth knowing
- C;Cnormal/common in clinvarNot rated
- C;Treduced risk (0.84x) for late-onset (adult) asthmaGood
- T;Treduced risk (0.73) for late-onset (adult) asthmaGood
rs1800629TNFWorth knowing
- A;Acomplex; generally higher risk for certain diseasesBad
- A;Gcomplex; generally higher risk for certain diseasesBad
- G;Gcomplex; generally normal riskGood
rs4986790TLR4Worth knowing
- A;AnormalGood
- A;GNo summary available.Not rated
- G;Gcomplex; numerous associations reportedBad
rs4986791TLR4Worth knowing
- C;CnormalGood
- C;Tcomplex; see detailsNot rated
- T;Tcomplex; see detailsNot rated
rs1695GSTP1Worth knowing
- A;Anormal asthma risk in certain populationsGood
- A;G?Not rated
- G;G3.5x asthma risk in certain populationsBad
rs37973GLCCI1Worth knowing
- A;Apossibly better response to inhaled corticosteroids in asthmaGood
- A;Glikely normal response to inhaled corticosteroids in asthmaGood
- G;Gpossibly weaker response to inhaled corticosteroids in asthmaBad
rs1361600F3Worth knowing
- T;TNo summary available.Not rated
- C;C~2x increased risk for adult-onset asthma in Japanese populationsBad
rs2305480GSDMBWorth knowing
- G;GnormalGood
- A;G3.5x increase in risk of asthma for Han ChineseBad
- A;Aif 4 years old or younger, ~3x increased asthma risk if exposed to smokeBad
rs4794067TBX21Worth knowing
- C;C2.1x risk for Aspirin Induced Asthma. But possibly lower risk of lupus and intractable Graves' disease.Not rated
- C;T2.1x risk for Aspirin Induced Asthma. But possibly lower risk of intractible Grave's disease.Not rated
- T;TLower risk of Aspirin Induced Asthma. Normal (higher) risk of lupus and intractable Grave's Disease.Not rated
rs4950928CHI3L1Worth knowing
- C;CNormal (higher) risk of Asthma.Bad
- C;GHalf the risk (maybe) of Asthma.Good
- C;GHalf the risk (maybe) of Asthma.Good
- G;GHalf the risk (maybe) of Asthma.Good
rs7216389GSDMBWorth knowing
- C;C0.69x lower risk of Childhood Asthma.Good
- C;TNormal risk for Childhood Asthma.Not rated
- T;T1.5x increased risk for Childhood Asthma.Bad
rs11650354TBX21Worth knowing
- C;Ccommon/normalGood
- C;Tpossible risk for allergic asthmaBad
- T;T8x risk for allergic asthmaBad
rs13153971SLC6A7Worth knowing
- C;C1.58x higher risk of Asthma.Bad
- C;TNormal (higher) risk of Asthma.Bad
- T;TLower 0.63x risk of Asthma.Good
rs2278206INPP4AMinor
- C;TNo summary available.Not rated
- G;Gpossibly less susceptible to asthmaGood
- A;GnormalNot rated
- A;A1.16x increased risk for asthmaBad
rs1042713ADRB2Minor
- A;A1.7x increased risk that pediatric inhaler use may make asthma worseBad
- A;G1.3x increased risk that pediatric inhaler use may make asthma worseBad
- G;GnormalNot rated
rs4129267IL6RMinor
- C;CNo increased risk of higher IL-R and CRP levelsGood
- T;TAssociated with 73% higher IL-R and CRP levelsBad
rs5067NPPATypical
- A;AnormalNot rated
- A;G0.5x reduced risk for asthmaNot rated
- G;G0.5x reduced risk for asthmaGood
rs569108MS4A2Typical
- T;TNo summary available.Not rated
- G;G?Not rated
- A;G3x risk of predisposition to childhood asthma in a Japanese populationBad
- A;AnormalGood
rs574174ADAM33Typical
- C;CNo summary available.Not rated
rs612709ADAM33Typical
- G;GNo summary available.Not rated
rs689465PTGS2Typical
- T;T1.5x increased risk for mild asthmaNot rated
- C;T1.35x increased risk for asthmaNot rated
- C;CnormalNot rated
rs1800925TH2LCRRTypical
- C;Ccommon/normalGood
rs1805018PLA2G7Typical
- A;Acommon in complete genomicsGood
rs2074190TBX21Typical
- G;G2.2x risk for AIANot rated
- A;G2.2x risk for AIANot rated
- A;AcommonNot rated
rs2240017TBX21Typical
- G;Gnot observed (too rare)Not rated
- C;Grespond better to steroidsNot rated
- C;CcommonGood
rs2251746FCER1ATypical
- C;Clowest IgE levelsNot rated
- C;Tlower IgE levelsNot rated
- T;Tnormal but highest IgE levelsNot rated
rs2303067SPINK5Typical
- A;A1.8x riskNot rated
- A;G?Not rated
- G;GnormalNot rated
rs2427837FCER1ATypical
- A;Alowest IgE levelsNot rated
- A;Glower IgE levelsNot rated
- G;Gnormal but highest IgE levelsNot rated
rs3804100TLR2Typical
- C;Csomwhat increased risk for type-1 diabetes and allergic asthmaNot rated
- C;Tsomewhat increased risk for type-1 diabetes and allergic asthmaNot rated
- T;TnormalGood
rs4795400GSDMBTypical
- C;CnormalNot rated
- C;TnormalNot rated
- T;Tif 4 years old or younger, ~2.5x increased asthma risk if exposed to smokeBad
rs8069176Typical
- A;AnormalNot rated
- A;GnormalNot rated
- G;Gif 4 years old or younger, ~3x increased asthma risk if exposed to smokeNot rated
rs10197862IL1RL1Typical
- A;Acommon in complete genomicsGood
rs11569562C3Typical
- G;Gincreased risk for adult asthmaNot rated
- A;G?Not rated
- A;AnormalNot rated
rs16947078TBX21Typical
- A;AcommonNot rated
- A;Gpossible risk for allergic asthmaNot rated
- G;G8x risk for allergic asthmaNot rated
rs17334242ADRB2Typical
- A;ANo summary available.Not rated
rs35699176ZNF77Very important
- G;Gcommon/normalGood
- A;GHigher risk for fungal spore related issues in lungs; risk worse in asthmatics?Bad
rs146597587IL33Worth knowing
- C;GReduced odds of developing asthmaGood
- G;Gcommon/normalGood

Genes

Genosets

Gs110Higher allergic asthma riskWorth knowing

Genosets combine several genotypes. Twofold checks them in your report.

Other SNPs

No notable genotype or detailed notes

Show 28 SNPs

Source and license

Adapted from Asthma on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.