rs1800925
A SNP in the TH2LCRR gene on chromosome 5. Its most notable genotype is C;C: common/normal
- Gene
- TH2LCRR
- Location
- Chr 5132,657,117 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 24%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 180 words
asthma related This SNP is in the promoter region of the IL-13 gene PMID 17615386 IL-13 is involved in pulmonary inflammation, remodeling and susceptibility to chronic obstructive pulmonary disease (COPD). This IL13 promoter polymorphism may modulate the adverse effects of cigarette smoking on pulmonary function in long-term cigarette smokers. Every 20 pack-year increment in smoking was associated with a 2.4% reduction in mean ppFEV1(forced expiratory volume in 1 second, a measure used to assess lung disease, like COPD) in the common homozygous (CC) or heterozygous (CT) promoter genotypes, and an 8.2% reduction in mean ppFEV1 in minor allele homozygotes (TT, recessive model). *pack-year= packs per day x years smoked rs1800925 and/or rs11568506 related to psoriasis and/or Crohn's disease ? rs324013 and rs1800925 influence transcription factor binding. These results are consistent with the Th2 cytokine pathway enhancing resistance to schistosome infection. Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria
Source and license
Adapted from rs1800925 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.